Table 3.
Characteristics of the moderately increased albuminuria sub study sample, examining albumin creatinine ratio (ACR)
| HUNT 2 (1995–1997) | No dementia | Total Dementia | Combined AD/VaD/Mixed AD/VaD | AD | VaD | Mixed AD/VaD | Other Dementia | P value A |
|---|---|---|---|---|---|---|---|---|
| Total Sample | 6810 | 214 | 176 | 109 | 44 | 23 | 38 | |
| ACR, mg/mmol mean (SD) | 1.70 (3.06) | 1.94 (3.37) | 1.95 (3.47) | 2.27 (4.31) | 1.68 (1.20) | .97 (.50) | 1.87 (2.89) | .26 |
| ACR, quartiles, n (%) | .01 | |||||||
| 0–.53 | 1561 (22.9) | 32 (15.0) | 25 (14.2) | 18 (16.5) | 4 (9.1) | 3 (13.0) | 7(18.4) | |
| .54–.87 | 2232 (32.8) | 70 (32.7) | 58 (33.0) | 36 (33.0) | 10 (22.7) | 12 (52.2) | 12 (31.6) | |
| .88–1.77 | 1695 (24.9) | 55 (25.7) | 47 (26.7) | 26 (23.9) | 14 (31.8) | 7 (30.4) | 8 (21.1) | |
| 1.78+ | 1322 (19.4) | 57 (26.6) | 46 (26.1) | 29 (26.6) | 16 (36.4) | 1 (4.3) | 11 (28.9) | |
| Diabetes Mellitus, n (%) | 1075 (15.8) | 31 (14.5) | 28 (15.9) | 16 (14.7) | 7 (15.9) | 5 (21.7) | 3 (7.9) | .61 |
| Antihypertensive tablets, n (%) | 4569 (67.1) | 168 (78.5) | 136 (77.3) | 80 (73.4) | 40 (90.9) | 16 (69.6) | 32 (84.2) | .00 |
| Sex, Female, n (%) | 3665 (53.8) | 133 (62.1) | 114 (64.8) | 77 (70.6) | 22 (50.0) | 15 (65.2) | 19 (50.0) | .02 |
| Age at HUNT 2 (1995–1997), mean (SD) | 60.44 (14.74) | 71.16 (6.49) | 71.67 (6.43) | 72.06 (6.16) | 70.40 (7.25) | 72.27 (5.91) | 68.80 (6.37) | .00 |
| Time to debut, years, mean (SD) | 7.16 (3.74) | 7.19 (3.85) | 7.25 (4.03) | 7.30 (3.82) | 6.69 (3.06) | 7.00 (3.22) | ||
| Education, n (%) | .01 | |||||||
| Primary | 3766 (55.3) | 141 (65.9) | 120 (68.2) | 76 (69.7) | 28 (63.6) | 16 (69.6) | 21 (55.3) | |
| Completed secondary | 2726 (40.0) | 68 (31.8) | 51 (29.0) | 32 (29.4) | 12 (27.3) | 7 (30.4) | 17 (44.7) | |
| Completed upper secondary | 318 (4.7) | 5 (2.3) | 5 (2.8) | 1 (.9) | 4 (9.1) | 0 | 0 | |
| eGFR, mean (SD) | 69.89 (15.63) | 61.31 (12.76) | 60.52 (12.53) | 59.92 (11.76) | 62.53 (15.31) | 59.55 (10.05) | 64.96 (13.34) | .00 |
| Cholesterol (mmol/L), mean (SD) | 6.24 (1.25) | 6.69 (1.28) | 6.78 (1.24) | 6.87 (1.25) | 6.70 (1.19) | 6.48 (1.25) | 6.27 (1.42) | .00 |
| Non-fasting blood glucose (mmol/L), mean (SD) | 6.19 (2.44) | 6.30 (2.34) | 6.28 (2.26) | 6.36 (2.45) | 6.19 (2.00) | 6.05 (1.79) | 6.42 (2.73) | .51 |
| Serum iron (), mean (SD) | 16.36 (5.98) | 15.62 (5.50) | 15.32 (5.26) | 15.47 (5.19) | 15.34 (5.57) | 14.57 (5.17) | 17.00 (6.38) | .07 |
| BMI (kg/m2) mean (SD) | 28.03 (4.54) | 28.29 (4.31) | 28.43 (4.20) | 28.31 (4.04) | 29.11 (4.92) | 27.74 (3.44) | 27.61 (4.78) | .41 |
| Pulse (beats/min), mean (SD) | 72.40 (13.64) | 72.38 (13.64) | 72.23 (12.77) | 72.06 (12.88) | 71.99 (1.78) | 73.52 (14.47) | 73.05 (17.31) | .98 |
| Systolic BP (mmHg), mean (SD) | 149.65 (23.29) | 159.80 (24.26) | 160.01 (21.19) | 159.48 (23.49) | 160.09 (24.45) | 162.35 (27.74) | 158.84 (24.90) | .00 |
| Diastolic BP (mmHg), mean (SD) | 85.27 (12.58) | 88.34 (13.13) | 88.22 (12.53) | 87.24 (12.59) | 90.36 (12.23) | 88.74 (12.76) | 88.89 (15.81) | .00 |
| Myocardial Infarction, n (%) | 581 (8.5) | 19 (8.9) | 13 (7.4) | 10 (9.2) | 3 (6.8) | 0 | 6 (15.8) | .86 |
| Angina Pectoris, n (%) | 918 (13.5) | 35 (16.4) | 27 (15.3) | 20 (18.3) | 4 (9.1) | 3 (13.0) | 8 (21.1) | .23 |
| Stroke, n (%) | 332 (4.9) | 16 (7.5) | 14 (8.0) | 5 (4.6) | 8 (18.2) | 1 (4.3) | 2 (5.3) | .08 |
| Daily Smoker, n (%) | 1347 (19.8) | 30 (14.0) | 24 (13.6) | 13 (11.9) | 8 (18.2) | 3 (13.0) | 6 (15.8) | .04 |
| Subjective health status | .01 | |||||||
| Poor, n (%) | 190 (2.8) | 5 (2.3) | 5 (2.8) | 3 (2.8) | 2 (4.5) | 0 | 0 | |
| Not so good, n (%) | 2739 (40.2) | 106 (49.5) | 84 (47.7) | 49 (45.0) | 22 (50.0) | 13 (56.5) | 22 (57.9) | |
| Good, n (%) | 3458 (50.8) | 98 (45.8) | 84 (47.7) | 55 (50.5) | 19 (43.2) | 10 (43.5) | 14 (36.8) | |
| Very good, n (%) | 423 (6.2) | 5 (2.3) | 3 (1.7) | 2 (1.8) | 1 (2.3) | 0 | 2 (5.3) |
AP-values are derived from t tests for continuous variables and x2 tests for the binary variables that compare means between total dementia and no dementia