Table 4.
Cox proportional regression models on the association of albumin creatinine ratio (ACR) presented as quartiles and number of cases with dementia with its subgroups. Hazard ratios are presented with 95% confidence intervals
| Total Dementia | NCA | Combined AD, VaD, Mixed AD/VaD | NC | AD | NC | VaD | NC | Mixed AD/VaD | NC | Other Dementia | NC | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DM or HTN medicationB | ACR | 184 | 151 | 90 | 42 | 19 | 33 | ||||||
| Model 1C | 0–.53 | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| .54–.87 | 1.43 (.90–2.28) | 1.64 (.96–2.80) | 1.31 (.67–2.56) | 2.03 (.55–7.51) | 3.41 (.75–15.58) | .88 (.33–2.36) | |||||||
| .88–1.77 | 1.57 (.98–2.53) | 1.84 (1.07–3.16) | 1.31 (.67–2.56) | 3.89 (1.12–13.53) | 2.51 (.51–12.46) | .84 (.30–2.41) | |||||||
| 1.78+ | 2.29 (1.43–3.65) | 2.55 (1.49–4.38) | 2.14 (1.12–4.09) | 5.92 (1.72–20.33) | .55 (.05–6.12) | 1.59 (.61–4.19) | |||||||
| Model 2D | 0–.53 | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| .54–.87 | 1.36 (.85–2.17) | 1.56 (.91–2.66) | 1.25 (.66–2.39) | 1.93 (.52–7.13) | 3.19 (.70–14.57) | .84 (.31–2.26) | |||||||
| .88–1.77 | 1.24 (.77–2.01) | 1.44 (.83–2.48) | 1.01 (.52–1.98) | 3.24 (.93–11.34) | 1.79 (.36–8.96) | .70 (.24–2.01) | |||||||
| 1.78+ | 1.71 (1.06–2.75) | 1.89 (1.10–3.26) | 1.60 (.83–1.98) | 4.52 (1.30–15.72) | .37 (.36–8.96) | 1.24 (.46–3.31) | |||||||
| Model 3E | 0–.53 | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| .54–.87 | 1.38 (.86–2.20) | 1.59 (.93–2.73) | 1.28 (.67–2.46) | 1.94 (.52–7.18) | 3.29 (.72–15.16) | .82 (.30–2.21) | |||||||
| .88–1.77 | 1.22 (.75–1.98) | 1.44 (.83–2.49) | 1.04 (.52–2.04) | 3.13 (.89–11.04) | 1.69 (.33–8.54) | .65 (.22–1.88) | |||||||
| 1.78+ | 1.66 (1.03–2.69) | 1.87 (1.08–3.25) | 1.61 (.83–3.13) | 4.35 (1.24–15.28) | .34 (.03–3.86) | 1.12 (.41–3.04) | |||||||
| Model 4F | 0–.53 | Ref | Ref | Ref | Ref | Ref | Ref | ||||||
| .54–.87 | 1.38 (.86–2.21) | 1.60 (.93–2.74) | 1.30 (.68–2.50) | 1.82 (.49–6.76) | 3.78 (.82–17.54) | .83 (.31–2.24) | |||||||
| .88–1.77 | 1.23 (.76–2.00) | 1.46 (.84–2.53) | 1.07 (.54–2.12) | 2.93 (.83–10.40) | 1.87 (.37–9.53) | .61 (.21–1.78) | |||||||
| 1.78+ | 1.65 (1.02–2.69) | 1.85 (1.06–3.23) | 1.66 (.85–3.24) | 3.97 (1.12–14.07) | .36 (.03–4.08) | 1.12 (.41–3.09) | |||||||
| ACR*Age | .11 | .09 | .91 | .15 | .24 | .86 | |||||||
| ACR*Sex | .46 | .38 | .44 | .77 | .20 | .09 |
A Number of dementia cases
B Self-reported history of Diabetes mellitus (DM) or hypertension (HTN) medication users
C Model 1: albumin creatinine ratio, quartiles (ACR)
D Model 2: ACR, age, sex, education
E Model 3: ACR, age, sex, education, glomerular filtration rate, cholesterol, non-fasting blood glucose, serum iron, body mass index, pulse
F Model 4: ACR, age, sex, education, glomerular filtration rate, cholesterol, non-fasting blood glucose, serum iron, body mass index, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status
Bold entries where adverse and inverse associations which are significant in this table