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. 2019 Apr 24;3(8):1445–1456. doi: 10.1210/js.2019-00082

Table 2.

Sexuality in Sexually Active Male Patients With 21-Hydroxylase Deficiency

Parameter Cohort Result Normal Population
Results Details Reference
Sexual orientation, n = 91
 Heterosexual 82 (90.1%) 94.2% Males and females from the UK, >16 y [38]
 Homosexual 3 (3.3%) 0.9%
 Bisexual 1 (1.1%) 0.5%
 Other 2 (2.2%) 0.5%
 To no one 3 (3.3%) No response: 3.2%
Age at sexual debut, median (range), n = 80 17 y (16–18) Mean: 16.5 y Males and females from the EU, 16–20 y [41]
Sexual activity, n = 91
 Nearly daily and 1–2/wk 37 (44.3%) Study 1: 1.4/wk Males from SE, 18–60 y [42]
 1–2/mo 24 (22.6%) Study 2: 1.9/wk Males from FR, >35 y [43]
 1–2/y and no sexual activity in past y 7 (6.6%)
 No sexual partner 28 (26.4%)
Satisfaction with sex life, n = 91a 3.5 ± 1.1 3.7 ± 1.31 Males from SE, 18–60 y [42]
Fears of sexual activities, n = 91 4 (4.4%)
Dislike of sexual activities, n = 91 4 (4.4%)
Lack of sexual desire, n = 91 16 (17.6%) Study 1: 11.97% Males from EU, 40–80 y [44]
Study 2: 11.7%–15.7% Males from ES and DE, 55 y [49]
Excessive sexual desire, n = 91 21 (23.1%) 5%–10% Males from SE, 18–60 y [42]
Difficulties getting aroused, n = 91 11 (12.1%)
Difficulties reaching an orgasm, n = 91 10 (11.0%)
Premature ejaculation, n = 91 23 (25.3%) Study 1: 20.2% Males from EU, 40–80 y [44]
Study 2: 20%–20.3% Males from IT and DE, 41.6 y [51]
Study 3: 25%–40% Males (global), all ages [52]
Study 4: 3%–30% International: all ages [33, 53]
No or incomplete erection, n = 91 17 (18.7%) Study 1: 12.5% Males from EU, 40–80 y [44]
Study 2: 12% Males from DE, UK, FR, 52.6 y [50]
Study 3: 17.4% Males from IT, ES, 20–75 y [49]
Study 4: 23% Males from DE, 18–79 y [48]

Abbreviations: DE, Germany; ES, Spain; EU, European Union; FR, France; IT, Italy; SE, Sweden; UK, United Kingdom.

a

Self-reported satisfaction with sexual life rated on a 5-point Likert scale from very dissatisfied (1) to very satisfied (5).