Table 1.
Postnatal recombinant construct | Mineralized tissue types | |
---|---|---|
1 | pDE-T + pDM-T | 9/12 (75%) Mineralized tissue formation 1/12 (8%) Tooth crowns with dentin and enamel |
2 | pDE-T + hDM-C | 6/12 (50%) Mineralized tissue formation 1/12 (8%) Tooth crowns with dentin and enamel 12/12 (100%) Enamel matrix |
3 | pDE-T + S | 6/12 (50%) Mineralized tissue formation 1/12 (8%) Tooth crowns with dentin and enamel 12/12 (100%) Enamel matrix |
4 | pDE-C + pDM-C | 2/12 (17%) Mineralized tissue formation 1/12 (9%) Tooth crowns with dentin and enamel |
5 | hGE-C + hDM-C | 1/12 (8%) Mineralized tissue formation |
6 | hGE-C + pDM-T | 1/12 (8%) Mineralized tissue formation |
7 | pDM-T + S | 0/12 (0%) Mineralized tissue formation |
hDM-C, human dental pulp-derived dental mesenchymal cells; hGE-C, human gingival epithelial cells; pDE-C, porcine dental epithelial cells; pDM-C, porcine dental mesenchymal cells; pDM-T, porcine dental mesenchymal tissue; pDE-T, porcine dental epithelial tissue; S, acellular collagen scaffold.