Table 4.
Selected List of Animal Studies on the Use of Vitamin Metabolites or Analogs on Cancer
| Cancer | Author | Study Design | Results |
|---|---|---|---|
| Colorectal | Newmark et al. (273) | Western diet | Ca + D prevents |
| Murillo et al. (274) | Chemical induced | D prevents | |
| Yang et al. (275) | APCmin + Western diet | Ca + D prevents | |
| Xu et al. (276) | APCmin + D-deficient diet | D + 1,25(OH)2D prevents | |
| Zheng et al. (277) | APCmin in VDRKO | ↑ Cancers | |
| Huerta et al. (278) | APCmin + D-deficient diet | 1,25(OH)2 D prevents | |
| Breast | Lipkin and Newmark (279) | DMBA + Western diet | Ca + D prevents |
| Zinser and Welsh (280) | DMBA + VDRKO | ↑ Cancers | |
| Zinser and Welsh (281) | MMTV-neu + VDRKO | ↑ Cancers | |
| VanWeelden et al. (282) | MCF-7 xenografts | EB1089 ↓ growth | |
| Ooi et al. (283) | Tumor inspections | D deficiency ↑ | |
| El Abdaimi et al. (284) | Xenograft breast cancer | EB1089 ↓ growth | |
| Prostate | Bhatia et al. (285) | Xenograft prostate cancer | EB1089 ↓ growth and mets |
| Zheng et al. (286) | PC3 cells in bone | Deficiency ↑ growth | |
| Mordan-McCombs et al. (287) | LPB-tag model | 1,25(OH)2D ↓ progression | |
| Krishnan et al. (288) | TRAMP model | 1,25(OH)2D ↓ growth | |
| Chung et al. (265) | TRAMP model + VDRKO | ↑ Angiogenesis |