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. Author manuscript; available in PMC: 2019 Dec 5.
Published in final edited form as: Nature. 2019 Jun 5;570(7762):528–532. doi: 10.1038/s41586-019-1276-2

Figure 1. Circulating ILCs are depleted and activated in response to TB.

Figure 1.

(a) Circulating ILC subsets were enumerated in blood of HIV+ and HIV− TB participants, and healthy controls by flow cytometry. Significance by Kruskal-Wallis test with corrections for multiple comparisons. (b) Paired ILC subsets in the blood before and after standard TB treatment were compared to frequencies in healthy controls (p-value by Wilcoxon matched-pairs test). Pre-TRT = untreated; TRT = after treatment. (c) The median fluorescent intensity (MFI) of the anti-apoptotic marker BCL2 was measured in TB+ and control participants on all ILC subsets, and in CD56hi NK cells, but not CD56dim NKs, CD4+, CD4−CD3+ T cells and CD19-expressing B cells. Significance by unpaired Mann-Whitney U test with Bonferroni corrections. (d) Expression of activation and pro-survival marker CD25 was determined using flow cytometry in ILC subsets in blood from HIV+ and HIV− TB participants. Significance by Kruskal-Wallis test with corrections for multiple comparisons.