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. Author manuscript; available in PMC: 2019 Dec 5.
Published in final edited form as: Nature. 2019 Jun 5;570(7762):528–532. doi: 10.1038/s41586-019-1276-2

Extended Data Figure 7. VIP and OSM are expressed within human TB infected lung tissue.

Extended Data Figure 7.

(a) VIP and (b) OSM protein expression was confirmed in situ in TB-infected human lung tissues using multiplexed fluorescent immunohistology. (c) The network of upstream drivers enriched in the differentially expressed genes in sorted ILC3s between TB infected and uninfected samples are shown. Inset: GO Network generated over the genes identified as downstream of OSM by IPA (n=64, see Methods). Each node represents a specific GO/KEGG/Reactome term (Supplementary Table 4). Broad categories of pathways are annotated. Line width/darkness corresponds to number of shared genes between nodes. Node size: ** p<0.01, *** p<0.001. (d) Select predicted downstream pathways enriched in the differentially expressed genes in ILC3s between TB infected and uninfected samples are shown.