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. Author manuscript; available in PMC: 2019 Dec 5.
Published in final edited form as: Nature. 2019 Jun 5;570(7762):528–532. doi: 10.1038/s41586-019-1276-2

Figure 3. ILCs demonstrate a structured response to PTB at the transcriptomic level.

Figure 3.

(a) Lung ILC2s and ILC3s were sorted and differential gene expression between TB infected (n=5) and uninfected control tissue (n=2) were determined by RNA sequencing. (b) Expression of key chemokines and chemoattractant proteins significantly upregulated in pulmonary ILCs from TB participants (Pos, n=5) when compared to uninfected control lungs is shown (Neg, n=2). p-values corrected using Benjamini-Hochberg with a significance cut-off of FDR < 0.01. (c) Upstream drivers of differentially expressed genes in ILC2s and ILC3s were predicted using Ingenuity Pathway Analysis (IPA). p-values calculated by hypergeometric test between genes in our data and known interactions in the literature for each driver.