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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: J Periodontal Res. 2019 Feb 25;54(4):444–452. doi: 10.1111/jre.12646

Figure 1. Effect of vitamin D deficiency on alveolar bone loss and inflammation.

Figure 1.

Mice (n=5 per group) fed a normal diet or vitamin D/calcium-deficient diet were sacrificed at the end of the 6-week diet. A. Serum 25(OH)D3 levels after 6 weeks. Maxillae were de-calcified and processed for micro-Ct and histology. B. MicroCT analysis of bone loss. Below the image is the quantification of bone area/tissue area (arrow indicated region of interest). C. Histological analysis of TRAP positive cells. Quantification of osteoclasts above a selected histological image of TRAP staining. Arrow indicates TRAP positive osteoclasts. Scale bar = 200μm. D. Inflammatory score of gingivae. Data in graphs are presented as mean +/− SEM. **P<0.01, ***P<0.001 using 2-tailed, unpaired t-tests.