Table 3.

Long-term outcomes for red blood cells transfused, compared with 0 or 1 units, after multivariable analyses^a

Outcome, RBC units	N	No. with events	HR (95% CI)	P	Overall P
Overall survivalb					<0.0001
0 or 1	4549	2044	Reference
2	149	102	1.55 (1.26–1.91)	<0.0001
3 to 7	117	85	2.02 (1.61–2.53)	<0.0001
≥8	32	29	4.29 (2.91–6.33)	<0.0001
Disease-free survivalb					<0.0001
0 or 1	4549	2377	Reference
2	149	113	1.44 (1.19–1.76)	<0.0001
3 to 7	117	90	1.85 (1.49–2.30)	<0.0001
≥8	32	30	3.57 (2.45–5.21)	><0.0001
Recurrencec					0.0099
0 or 1	4549	1286	Reference
2	149	64	1.35 (1.04–1.75)	0.023
3 to 7	117	41	1.50 (1.09–2.07)	0.013
≥8	32	9	1.58 (0.80–3.10)	0.187

CI, confidence interval; HR, hazard ratio; RBC, red blood cell.

^aSee Supplementary Tables 1, 2 and 3 for full multivariable models results.

^bCox proportional hazards model

^cCause-specific Cox model