Figure 6.

Uninjured SCID mice showed worse behavior performance in MWM. (A) The test of initial swimming distance (m) and swimming speed (m/s) before training showed no significant differences between two genotypes (mean ± SEM; n = 15, P > 0.05, unpaired Student’s t-test). (B) Upper panels (in red) shows the escape latency for mice to reach the hidden platform during forward acquisition training phases, as well as traverses through the platform zone and the latency to first reach the platform zone (mean ± SEM; n = 15, *P < 0.05, **P < 0.001, unpaired Student’s t-test). The lower panel (in blue) shows the exact same results in reverse test (acquisition phase and probe trial). (C) Representative swimming traces of SCID and WT mice during acquisition training phases and probe trial