Table 4.
Results of Cox multivariable regression models (adjusted for age, gender, Elixhauser and Charlson comorbidity indices)
| Transcatheter mitral valve repair |
Transcatheter aortic valve replacement |
P-value for interaction | |||
|---|---|---|---|---|---|
| Hazard ratio (95% CIs) | P-value | Hazard ratio (95% CIs) | P-value | ||
| All-cause mortality | |||||
| Hospital Frailty Risk Score | 1.060 (1.050–1.070) | <0.001 | 1.062 (1.058–1.067) | <0.001 | 0.258 |
| Hospital Frailty Risk Category | <0.001 | <0.001 | |||
| Intermediate risk (5–15) | 2.257 (1.858–2.743) | <0.001 | 1.931 (1.762–2.117) | <0.001 | |
| High risk (>15) | 3.192 (2.437–4.180) | <0.001 | 3.644 (3.214–4.132) | <0.001 | |
| Rehospitalization for any cause | |||||
| Hospital Frailty Risk Score | 1.061 (1.053–1.069) | <0.001 | 1.061 (1.058–1.064) | <0.001 | 0.151 |
| Hospital Frailty Risk Category | <0.001 | <0.001 | |||
| Intermediate risk (5–15) | 1.714 (1.526–1.924) | <0.001 | 1.648 (1.579–1.719) | <0.001 | |
| High risk (>15) | 2.722 (2.306–3.214) | <0.001 | 2.920 (2.739–3.112) | <0.001 | |
| Rehospitalization due to acute myocardial infarction (I21, at subsequent index) | |||||
| Hospital Frailty Risk Score | 1.050 (1.001–1.101) | 0.047 | 1.079 (1.063–1.095) | <0.001 | 0.192 |
| Hospital Frailty Risk Category | <0.001 | <0.001 | |||
| Intermediate risk (5–15) | 2.031 (1.183–3.486) | <0.001 | 2.158 (1.800–2.587) | <0.001 | |
| High risk (>15) | 4.483 (2.257–8.904) | <0.001 | 4.250 (3.305–5.465) | <0.001 | |
| Rehospitalization due to acute renal failure (N17, at subsequent index) | |||||
| Hospital Frailty Risk Score | 1.073 (1.057–1.088) | <0.001 | 1.072 (1.064–1.079) | <0.001 | 0.355 |
| Hospital Frailty Risk Category | <0.001 | <0.001 | |||
| Intermediate risk (5–15) | 1.907 (1.585–2.295) | <0.001 | 1.813 (1.667–1.971) | <0.001 | |
| High risk (>15) | 3.391 (2.639–4.351) | <0.001 | 3.473 (3.085–3.910) | <0.001 | |
| Rehospitalization due to acute heart failure (I5021, I5031, I5041, I5023, I5033, I5043 at subsequent index) | |||||
| Hospital Frailty Risk Score | 1.058 (1.044–1.072) | <0.001 | 1.068 (1.062–1.075) | <0.001 | 0.160 |
| Hospital Frailty Risk Category | <0.001 | <0.001 | |||
| Intermediate risk (5–15) | 1.738 (1.471–2.054) | <0.001 | 1.892 (1.742–2.054) | <0.001 | |
| High risk (>15) | 2.869 (2.279–3.613) | <0.001 | 3.509 (3.128–3.936) | <0.001 | |
| Rehospitalization due to stroke or TIA (I63 and G45, at subsequent index) | |||||
| Hospital Frailty Risk Score | 1.065 (1.021–1.110) | 0.003 | 1.074 (1.059–1.089) | <0.001 | 0.821 |
| Hospital Frailty Risk Category | 0.035 | <0.001 | |||
| Intermediate risk (5–15) | 1.511 (0.927–2.462) | 0.097 | 1.918 (1.619–2.274) | <0.001 | |
| High risk (>15) | 4.546 (2.534–8.161) | <0.001 | 4.061 (3.204–5.146) | <0.001 | |
| Rehospitalization due to acute post-haemorrhagic anaemia (D62, at subsequent index) | |||||
| Hospital Frailty Risk Score | 1.043 (1.015–1.071) | 0.002 | 1.043 (1.032–1.058) | <0.001 | 0.806 |
| Hospital Frailty Risk Category | 0.001 | <0.001 | |||
| Intermediate risk (5–15) | 1.620 (1.228–2.137) | 0.001 | 1.636 (1.474–1.816) | <0.001 | |
| High risk (>15) | 2.049 (1.325–3.168) | 0.001 | 2.266 (1.914–2.683) | <0.001 | |
For each outcome, two separate (continuous and categorical scale) models were built (low-risk group handled as a reference for category groups; hazard ratio = 1).