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. Author manuscript; available in PMC: 2019 Jul 14.
Published in final edited form as: Biochem Biophys Res Commun. 2018 Apr 4;499(3):556–562. doi: 10.1016/j.bbrc.2018.03.189

Fig. 2.

Fig. 2.

Compound characterization in malachite green GTPase activity assay. (a) Dose response curves in the presence of liposomes for three 1H-pyrrole-2-carboxamide compounds and mdivi-1. Compound 4 is a full inhibitor, with maximum inhibition of greater than 75% DRP1 activity. Compound 7 is a partial inhibitor, with maximum inhibition of 40—60% DRP1 activity. Compound 11 and mdivi-1 do not inhibit DRP1 up to 100 μM compound concentration. (b) Dose response curves in the presence and absence of liposomes for 4 and 7. The potencies of both compounds decrease in the absence of liposomes; 7 is inactive in the absence of liposomes, while 4 is still active at higher concentrations. (c) Dose response curves in the presence and absence of liposomes for GTPγS. The potency of GTPγS is unaffected by liposomes.