. Author manuscript; available in PMC: 2019 Jul 14.

Published in final edited form as: Biochem Biophys Res Commun. 2018 Apr 4;499(3):556–562. doi: 10.1016/j.bbrc.2018.03.189

Table 2.

Structure-activity relationship of pyrrole and thiazole constituents of 1H-pyrrole-2-carboxamide compounds. IC₅₀ values and max % inhibition were determined as in Table 1. DYN1 = dynamin-1.

			IC50 (μM)			Max % inhibition

	R1	R2	DRP1	OPA1	DYN1

8	Cl		2.3	>100	>100	77
9	Ph		1.5	>100	>100	l9
10	Me		2.1	>100	>100	80
11	Me		>100	>100	>100	6