Table 3.
In vitro ADME results for selected inhibitors.
| Kinetic solubility at pH l.4 (μM) | RLM Clint (μL/min/mg protein) | Caco-2 permeability (Papp A>B/B>A 10−6cm-s−1) | |
|---|---|---|---|
| 2 | 186 | 6.8 | 1l/13 |
| 4 | 19l | 21 | 18/46 |
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