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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Tuberculosis (Edinb). 2019 Apr 26;116 Suppl:S114–S117. doi: 10.1016/j.tube.2019.04.018

Figure 1. C57BL/6 mice immunized with BCG and lactoferrin demonstrate long lasting diminished inflammation and destructive pulmonary histopathology upon aerosol challenge with virulent MTB.

Figure 1.

Mice demonstrated reduced histological manifestation of disease in the BCG and recombinant human lactoferrin immunized group at day 150 post challenge with <100 CFU Erdman strain (methods detailed in (49, 51)). Activated monocytes are apparent in the BCG and non-immunized groups (arrows). Lactoferrin adjuvant immunized mice revealed reduction in alveolitis with evidence of lymphocytic clusters and limited focal pockets of inflamed monocytes. H&E staining (20×; N≥5 mice per group).