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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Psychopharmacology (Berl). 2019 Jun 3;236(7):2155–2171. doi: 10.1007/s00213-019-05208-0

Fig. 1. Summary of experimental events and brain regions dissected for the gene expression analyses in Experiment 1.

Fig. 1

(a) Effect of exercise during abstinence on relapse-like responding and associated gene expression changes: Following acquisition, rats were given 24-hr/day extended (ExA) access to cocaine under a discrete trial procedure for 10 days. After the last cocaine self-administration session, rats were housed without (sedentary, Sed, n=8) or with access to a running wheel (2-hr/day) during early (days 1-7; Early, n=14), late (days 8-14; Late, n=10), or throughout (days 1-14; Thru, n=8) a 14-day abstinence period. Additional rats were given access to saline and housed without access to a wheel during “abstinence” (saline, Sal, n=10). On day 15 of abstinence, rats underwent extinction/reinstatement testing, and on the morning following this 1-day test session, tissue was collected. (b) Schematic illustration of the brain regions dissected for the NAc core and the dmPFC.