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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Psychopharmacology (Berl). 2019 Jun 3;236(7):2155–2171. doi: 10.1007/s00213-019-05208-0

Fig. 3. Exercise initiated during early, but not late abstinence, reduces relapse-like responding.

Fig. 3

(a) No differences were observed between the cocaine groups that were later tested under sedentary (Sed) versus exercise during early (Early), late (Late), or throughout (Thru) abstinence. Significant difference from the last session (+) and from saline (bracket and #). (b) Levels of running (km) during the first seven exercise sessions were similar between the groups given access to exercise during early, late, and throughout abstinence. Significant difference from the last session (+). (c) Exercise during early and throughout, but not during late abstinence, decreased cocaine-seeking during extinction. Data are plotted as formerly-active lever responses for the first six extinction sessions. Significant difference from the last session (+), from saline (bracket and #), and from sedentary controls (bracket and *). (d) Each of the cocaine groups showed an increase in responding from the last extinction (Extinct) session to the reinstatement session, and this increase was markedly reduced by exercise during early and throughout, but not late abstinence. Data are plotted as formerly-active lever responses for the last extinction session versus the reinstatement session. Significant difference from the last extinction session (bar and +), from saline (#), and from sedentary controls (*). Sal, open symbols, n=10; Sed, filled symbols, n=8; Late, yellow and black symbols, n=10; Thru, yellow symbols, n=8; Early, yellow and white symbols, n=14.