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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Psychopharmacology (Berl). 2019 Jun 3;236(7):2155–2171. doi: 10.1007/s00213-019-05208-0

Fig. 7. Stimulation of mGlu5 in the dmPFC during early abstinence mimics the efficacy of exercise.

Fig. 7

(a)No differences were observed for the number of infusions obtained over the 10 extended access sessions between the groups that were later tested under sedentary (Sed-Veh and Sed-CHPG) versus exercise (Exer-Veh and Exer-MPEP) conditions. Significant difference from the last session (+) (b) Levels of running (km) during the seven exercise sessions were similar between groups given daily intra-dmPFC infusions of vehicle (Exer-Veh) or MPEP (Exer-Veh). Significant difference from the last session (+) (c) No differences were observed for cocaine-seeking during extinction. Data are plotted as formerly-active lever responses for the first six extinction sessions. Significant difference from the last session (+). (d) Exercise during early abstinence (Exer-Veh) blocked the reinstatement of cocaine-seeking (as observed in the Sed-Veh group); this effect of exercise was mimicked in sedentary rats given intra-dmPFC infusions during early abstinence (Sed-CHPG), but not affected by intra-dmPFC infusions of MPEP prior to the exercise sessions (Exer-MPEP). Data are plotted as formerly-active lever responses for the last extinction (Extinct) session versus the reinstatement session. Significant difference from the last extinction session (+) and from sedentary controls (*). (e) Representative micrographs from rats that received daily bilateral dmPFC infusions within each of the groups. Sed-Veh, filled symbols, n=6; Sed-CHPG, black and white symbols, n=8; Exer-Veh, yellow symbols, n=8; Exer-MPEP, yellow and white symbols, n=8.