Table 2.
Genes upregulated by Vit D treatment of THP-1 cells
| Function | Gene name | Role in TB |
|---|---|---|
| CXCL8 | Stimulator of phagocytosis | |
| Mediators of inflammatory response | IL1B | Caspase-1 activation. Stimulator of MIP-I alpha production |
| CCL22 | Lung inflammation through CCR4 activation | |
| Transcription Factor for Type I IFNs | IRF5 | Necessary for Type I IFN in response to Mtb |
| Recruitment of effector immune cells to site of inflammation | CXCL8 | Neutrophil chemoattractant |
| CCR1 | Receptor for CCL-3, −4, −5, and MIP-1 alpha | |
| CD38 | M1 polarization inflammatory marker in Mtb infection | |
| T cell chemoattractant | IL16 | Increased in TB pleural effusion |
| CCL22 | Lung inflammation through CCR4 activation | |
| CD86 | M1 polarization marker in Mtb infection | |
| T cell activation | CD84 | Increased in B cell precursors in Mtb infection |
| IL27RA | Involved in resolution of inflammation. Induced by Type I IFNs in Mtb infection | |
| Neutrophil and NK-mediated bacterial killing | CXCR1 | Oxidative defense in active TB |
| CD244 | Increased in lymphocytes of TB patients | |
| Antigen presentation | HLA-B,HLA-C | Restricting alleles for TB CD8 antigens |
| Pathogen Recognition Receptor | TLR8 | Enhances the innate and adaptive immune response |
| TLR5 | Expressed on myeloid cells in TB granulomas | |
| P2RX7 | Induces cell death and subsequent loss of intracellular bacterial viability in human macrophages infected with mycobacteria | |
| CD14 | Facilitates the uptake of non-opsonized Mtb | |
| Intracellular PRR | NOD2 | Enhances the innate response of alveolar macrophages to Mtb |
| AIM1 | IL-1β and IL-18 production and Th1 responses to Mtb | |
| TLR adapter | TIRAP | Influences disease susceptibility by modulating the inflammatory response |
| Regulated by Type I IFNs and MyD88 | IL10RA | Anti-inflammatory cytokine expressed in chronic Mtb granulomas |
| Serine protease inhibitors | SERPINB9 | Inhibits apoptosis and promotes survival of Mtb-infected macrophages |
| SERPING1 | Component of active TB signature | |
| SERPINB1 | Critical for neutrophil survival | |
| Complement degradation | CD46 | Bactericidal activity of macrophages and granuloma formation |
| Regulation of Inflammation | SIGLEC10 | Increased in CD14+CD16++ monocytes upon Mtb infection |
| SIGLEC14,SIGLEC5 | Involved in Mtb replication in monocytes |