Table 1.

Homeobox genes show different roles in the progression of hepatocellular carcinoma

Homeobox genes	Involvement in HCC process	Target genes	Ref.
HOXA13	Colony formation (+), migration (+), Drug resistance (+)	—	[65,67]
HOXA7	Proliferation (-)	Cyclin e1/cdk2	[68]
HOXB7	Stemness (+), EMT (+)	c-Myc, slug	[69]
HMBOX1	Autophagy (+), Stemness (-), Immunosuppression (-)	PD-L1, Fas	[75]
PROX1	Drug resistance (+), angiogenesis (+)	IL-8, NF-κB, β-catenin	[77-79]
NKX3.1	Proliferation (-)	FOXO1	[80]

(-): Inhibit; (+): Promote; -: Unavailable; HCC: Hepatocellular carcinoma.