Table 4.
Diagnostic performance of magnetic resonance elastography and two-dimensional shear wave elastography, fibrosis index based on four factors score, and aspartate transaminase-to-platelet ratio index for evaluation of significant fibrosis (≥ F2) and cirrhosis (F4)
| AUC (95%CI) | P value | Cutoff | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | ||
| MRE | ≥ F2 | 0.906 (0.806, 0.965) | < 0.001 | > 2.47 (kPa) | 81.8 | 94.7 | 97.3 | 69.2 |
| F4 | 0.894 (0.791, 0.958) | < 0.001 | > 3.46 (kPa) | 88.9 | 97.8 | 94.1 | 95.6 | |
| 2D-SWE | ≥ F2 | 0.843 (0.730, 0.923) | < 0.001 | > 6.73 (kPa) | 84.1 | 68.4 | 86.0 | 65.0 |
| F4 | 0.816 (0.698, 0.902) | < 0.001 | > 9.50 (kPa) | 77.8 | 80.0 | 60.9 | 90.0 | |
| FIB-4 | ≥ F2 | 0.697 (0.568, 0.806) | 0.003 | > 1.80 | 70.5 | 63.2 | 81.6 | 48.0 |
| F4 | 0.786 (0.665, 0.880) | < 0.001 | > 3.22 | 50.0 | 97.8 | 90.0 | 83.0 | |
| APRI | ≥ F2 | 0.717 (0.590, 0.823) | 0.001 | > 0.49 | 84.1 | 52.6 | 80.4 | 58.8 |
| F4 | 0.701 (0.572, 0.810) | 0.006 | > 0.96 | 50.0 | 84.4 | 562 | 80.9 |
MRE: Magnetic resonance elastography; 2D-SWE: Two-dimensional shear wave elastography; FIB-4: Fibrosis index based on four factors; APRI: Aspartate transaminase-to-platelet ratio index; AUC: Area under the curve; PPV: Positive predictive value; NPV: Negative predictive value.