Fig. 5.

Cellular uptake of gold nanoconstructs by U87 glioblastoma cells. A Transmission electron micrographs of Au nanoparticles displaying 13 nm spheres, 50 nm spheres and 40 nm stars; B cellular uptake kinetics of Au nanoparticles-siRNA constructs by cells showing size and shape dependent uptake; C transmission electron images illustrating the process of cellular uptake after treatment with 0.5 nM of Au nanoparticles-siRNA constructs for 24 h. The vesicle membranes disrupted by the treatment with 50 nm spheres is signified by orange arrows, and the nanoconstructs distributed outside the vesicles is represented by yellow arrows

(reproduced with permission from [103])