Table 1. Demographic and clinical data of 677 ESCC patients according to LC change.

Characteristics	Total (N=677), %	LC change		P
		Increased (N=95), %	Decreased (N=582), %
Sex				0.238
Male	579 (85.5)	85 (89.5)	494 (84.9)
Female	98 (14.5)	10 (10.5)	88 (15.1)
Age (years)	61 [56–67]	62 [57–69]	61 [55–66]	0.029
Pathology grade				0.338
Well differentiated	49 (7.4)	4 (4.3)	45 (7.9)
Middle differentiated	447 (67.3)	61 (64.9)	386 (67.7)
Poorly differentiated	166 (25.0)	29 (30.9)	137 (24.0)
Undifferentiated	2 (0.3)	0 (0)	2 (0.4)
Depth of tumor				0.926
T1a–1b	64 (9.5)	9 (9.5)	55 (9.5)
T2	131 (19.4)	17 (17.9)	114 (19.6)
T3	482 (71.2)	69 (72.6)	413 (71.0)
Lymph node metastasis				0.907
N0	295 (43.6)	44 (46.3)	251 (43.1)
N1	213 (31.5)	27 (28.4)	186 (32.0)
N2	117 (17.3)	17 (17.9)	100 (17.2)
N3 (≥3)	52 (7.7)	7 (7.4)	45 (7.7)
Pathological stage				0.928
1a–1b	116 (17.1)	17 (17.9)	99 (17.0)
2a–2b	228 (33.7)	33 (34.7)	195 (33.5)
3a–3c	333 (49.2)	45 (47.4)	288 (49.5)
Vessel invasive				0.664
Yes	208 (30.7)	31 (32.6)	177 (30.4)
No	469 (69.3)	64 (67.4)	405 (69.6)
Nerve infiltration				0.708
Yes	252 (37.2)	37 (38.9)	215 (36.9)
No	425 (62.8)	58 (61.1)	367 (63.1)
Treatment regimen				0.998
S	458 (67.7)	64 (67.4)	394 (67.7)
S plus postoperative C	155 (22.9)	22 (23.2)	133 (22.9)
S plus postoperative CRT	64 (9.5)	9 (9.5)	55 (9.5)
Hospital time (days)	11 [10–14]	12 [10–18]	11 (10–13.3)	0.020
Pre-LC (109/L), median	1.7 (1.3–2.0)	1.3 (1.0–1.6)	1.7 (1.4–2.1)	<0.001
Post-LC (109/L), median	1.1 (0.9–1.5)	1.6 (1.3–2.0)	1.1 (0.9–1.4)	<0.001

The data were shown as n (%) or median (interquartile range). P<0.05 marked in italic. ESCC, esophageal squamous cell carcinoma.