Table 2. Disease-free survival analyses according to LC change in 677 patients with ESCC.

Variables	Univariate				Multivariate
	HR	95% CI	P		HR	95% CI	P
LCc (decreased vs. increased)	0.593	0.409–0.862	0.006		0.617	0.424–0.897	0.011
Sex (male vs. female)	1.201	0.782–1.844	0.404
Age (>60 vs.≤60)	0.943	0.707–1.258	0.690
Pathology grade
Well differentiated	0.147	0.018–1.202	0.074
Middle differentiated	0.274	0.038–1.968	0.198
Poorly differentiated	0.427	0.059–3.090	0.399
Undifferentiated	1.000
Depth of tumor
T1a–1b	0.899	0.535–1.509	0.686
T2	0.726	0.492–1.071	0.107
T3	1.000
Lymph node metastasis
N0	0.222	0.135–0.364	<0.001		0.316	0.135–0.739	0.008
N1	0.348	0.213–0.568	<0.001		0.387	0.234–0.641	<0.001
N2	0.519	0.310–0.870	0.013		0.526	0.313–0.882	0.015
N3	1.000				1.000
Pathological stage
1a–1b	0.507	0.327–0.787	0.002		1.155	0.493–2.705	0.740
2a–2b	0.483	0.343–0.680	<0.001		0.873	0.460–1.657	0.677
3a–3c	1.000				1.000
Vessel invasive (absence vs. presence)	1.280	0.939–1.743	0.118
Nerve infiltration (absence vs. presence)	1.624	1.214–2.171	0.001		1.483	1.092–2.014	0.012
Treatment regimen
S	0.472	0.308–0.725	0.001		0.550	0.355–0.852	0.007
S plus postoperative C	1.123	0.718–1.758	0.611		1.063	0.677–1.670	0.791
S plus postoperative CRT	1.000				1.000
Hospital time (days) (>14 vs.≤14)	1.195	0.842–1.696	0.319		–	–	–

P<0.05 marked in italic. ESCC, esophageal squamous cell carcinoma.