Table 5. Univariate and multivariate analysis for recurrence of stage IA2 non-small cell lung cancer after lobectomy (n=235) and wedge resection (n=29) (Cox-proportional hazard model).
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Age | 1.006 | 0.971–1.042 | 0.731 | ||||
| Sex (male) | 2.703 | 1.231–5.937 | 0.013 | 1.460 | 0.471–4.530 | 0.512 | |
| Smoker | 2.215 | 1.065–4.606 | 0.033 | 1.220 | 0.409–3.635 | 0.721 | |
| CEA | 1.066 | 1.035–1.098 | <0.001 | 1.040 | 1.001–1.081 | 0.046 | |
| SUVmax | 1.185 | 1.077–1.303 | <0.001 | 1.100 | 0.966–1.252 | 0.151 | |
| Lobe | 0.995 | ||||||
| Right upper (reference) | 1 | ||||||
| Right middle | 1.238 | 0.271–5.669 | 0.783 | ||||
| Right lower | 1.091 | 0.396–3.004 | 0.867 | ||||
| Left upper | 1.228 | 0.467–3.231 | 0.677 | ||||
| Left lower | 1.127 | 0.353–3.600 | 0.841 | ||||
| FEV1 (%) | 1.010 | 0.988–1.032 | 0.371 | ||||
| DLCO (%) | 1.002 | 0.979–1.024 | 0.892 | ||||
| VATS | 0.461 | 0.211–1.005 | 0.052 | 0.505 | 0.204–1.253 | 0.141 | |
| Total tumor size | 0.630 | 0.296–1.339 | 0.229 | ||||
| Invasive component size | 3.749 | 1.018–13.809 | 0.047 | 2.318 | 0.539–9.974 | 0.259 | |
| Central location | 2.611 | 0.995–6.853 | 0.051 | 2.301 | 0.731–7.249 | 0.154 | |
| Histology | 0.497 | ||||||
| Adenocarcinoma (Reference) | 1 | 0.256 | |||||
| Squamous cell carcinoma | 1.848 | 0.640–5.334 | 0.807 | ||||
| others | 0.779 | 0.105–5.766 | |||||
| Number of dissected lymph nodes | 0.954 | 0.905–1.005 | 0.079 | 0.941 | 0.884–1.001 | 0.053 | |
| Lymphovascular invasion | 2.791 | 1.341–5.807 | 0.006 | 2.664 | 1.118–6.345 | 0.027 | |
| Wedge resection | 2.120 | 0.808–5.560 | 0.127 | ||||
CEA, carcinoembryonic antigen; SUVmax, maximum standardized uptake value; FEV1, forced expiratory volume in 1 second; DLCO, diffusing capacity for carbon monoxide; VATS, video-assisted thoracoscopic surgery.