Table S2. Clinical and dosimetric variable associations with grade 2+ lung toxicities.

Characteristic	All patients			Pneumonitis grade <2			Pneumonitis grade ≥2		P value
	No.	%		No.	%		No.	%
Total No. of patients	108	100.0		78	72		30	28	–
Age									0.24
<67 years	53	49		41	77		12	23
≥67 years	55	51		37	67		18	33
Gender									0.63
Female	58	54		43	74		15	26
Male	50	46		35	70		15	30
Race									0.22
Caucasian	57	53		44	77		13	23
Other	51	47		34	67		17	33
Smoking status									0.0006
Current smoker	25	23		24	96		1	4
Non-current smoker	83	77		54	65		29	35
Radiotherapy technique									0.41
3D CRT	85	79		63	74		22	26
IMRT	23	21		15	65		8	35
Pre-existing lung disease									0.16
Yes	53	49		35	66		18	34
No	55	51		43	78		12	22
Gross tumor volume									0.91
<98.6 cm3	55	51		40	73		15	27
≥98.6 cm3	53	49		38	72		15	28
Mean lung dose									0.16
<19.1 Gy	55	51		43	78		12	22
≥19.1 Gy	53	49		35	66		18	34
Lung V5									0.16
<59.8%	55	51		43	78		12	22
≥59.8%	53	49		35	66		18	34
Lung V20									0.07
<32.0%	54	50		44	81		11	20
≥32.0%	54	50		34	63		19	35

3D CRT, three-dimensional conformal radiation therapy; IMRT, intensity-modulated radiation therapy; Gy, gray.