Table 2. The association of the clinicopathological characteristics.
| Factors (n) | 0–44 | 45–49 | 50–54 | 55–59 | 60–64 | 65–69 | 70–74 | 75–79 | 80–84 | 85+ | P |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex | <0.01 | ||||||||||
| Female | 1,718 | 2,862 | 5,173 | 7,299 | 9,787 | 12,063 | 11,775 | 10,631 | 7,385 | 3,762 | |
| Male | 1,416 | 2,691 | 5,745 | 9,231 | 12,219 | 14,247 | 12,986 | 10,820 | 6,969 | 3,140 | |
| Race | <0.01 | ||||||||||
| White | 2,235 | 4,072 | 8,051 | 12,536 | 17,337 | 21,382 | 20,465 | 17,907 | 12,208 | 5,777 | |
| Black | 465 | 957 | 1,962 | 2,706 | 3,006 | 3,039 | 2,372 | 1,840 | 953 | 478 | |
| Others | 419 | 508 | 877 | 1,246 | 1,618 | 1,840 | 1,863 | 1,668 | 1,164 | 634 | |
| Unknown | 15 | 16 | 28 | 42 | 45 | 49 | 61 | 36 | 29 | 13 | |
| Histology | <0.01 | ||||||||||
| Adenocarcinoma | 2,633 | 4,363 | 8,180 | 11,743 | 14,841 | 16,955 | 15,505 | 13,276 | 9,041 | 4,548 | |
| Squamous | 501 | 1,190 | 2,738 | 4,787 | 7,165 | 9,355 | 9,256 | 8,175 | 5,313 | 2,354 | |
| Surgery | <0.01 | ||||||||||
| No | 2,147 | 3,801 | 7,441 | 10,958 | 14,188 | 16,429 | 15,941 | 14,433 | 10,745 | 5,974 | |
| Yes | 987 | 1,752 | 3,477 | 5,572 | 7,818 | 9,881 | 8,820 | 7,018 | 3,609 | 928 | |
| Radiation | <0.01 | ||||||||||
| No | 1,586 | 2,847 | 5,590 | 8,785 | 12,533 | 15,595 | 15,114 | 13,533 | 9,075 | 2,416 | |
| Yes | 1,490 | 2,624 | 5,168 | 7,483 | 9,159 | 10,301 | 9,252 | 7,648 | 5,070 | 4,396 | |
| Unknown | 58 | 82 | 160 | 262 | 314 | 414 | 395 | 270 | 209 | 90 | |
| LNM stage | <0.01 | ||||||||||
| Ia | 282 | 555 | 1,265 | 2,082 | 3,279 | 4,272 | 4,088 | 3,330 | 820 | 820 | |
| Ib | 254 | 488 | 948 | 1,626 | 2,550 | 3,403 | 3,291 | 3,119 | 1,009 | 1,009 | |
| IIa | 44 | 81 | 130 | 245 | 304 | 391 | 364 | 283 | 48 | 48 | |
| IIb | 105 | 259 | 479 | 772 | 1,008 | 1,353 | 1,165 | 1,034 | 276 | 276 | |
| IIIa | 255 | 476 | 1,052 | 1,601 | 2,128 | 2,654 | 2,465 | 2,098 | 592 | 592 | |
| IIIb | 484 | 867 | 1,738 | 2,663 | 3,504 | 3,989 | 3,998 | 3,626 | 1,553 | 1,553 | |
| IV | 1,684 | 2,764 | 5,200 | 7,350 | 9,003 | 9,923 | 9,050 | 7,625 | 2,437 | 2,437 | |
| Unknown | 26 | 63 | 106 | 191 | 230 | 325 | 340 | 336 | 167 | 167 | |
| N stage | <0.01 | ||||||||||
| N0 | 1,009 | 1,924 | 3,873 | 6,123 | 9,082 | 11,685 | 11,466 | 10,271 | 6,941 | 3,388 | |
| N1 | 289 | 584 | 1,050 | 1,685 | 2,192 | 2,605 | 2,284 | 1,980 | 1,264 | 527 | |
| N2 | 1,172 | 2,012 | 4,045 | 6,023 | 7,514 | 8,608 | 7,946 | 6,708 | 4,388 | 2,091 | |
| N3 | 546 | 888 | 1,649 | 2,251 | 2,657 | 2,714 | 2,366 | 1,789 | 1,164 | 510 | |
| Unknown | 118 | 145 | 301 | 448 | 561 | 698 | 699 | 703 | 597 | 386 | |
| Lymph node metastasis | <0.01 | ||||||||||
| No | 1,009 | 1,924 | 3,873 | 6,123 | 9,082 | 11,685 | 11,466 | 10,271 | 6,941 | 3,388 | |
| Yes | 2,007 | 3,484 | 6,744 | 9,959 | 12,363 | 13,927 | 12,596 | 10,477 | 6,816 | 3,128 | |
| Unknown | 118 | 145 | 301 | 448 | 561 | 698 | 699 | 703 | 597 | 386 | |
| Tumor location | <0.01 | ||||||||||
| Left | 1,854 | 3,216 | 6,457 | 9,601 | 12,652 | 15,123 | 14,116 | 12,236 | 8,148 | 3,841 | |
| Right | 1,150 | 2,175 | 4,204 | 6,562 | 8,935 | 10,694 | 10,222 | 8,829 | 5,901 | 2,858 | |
| Paired sites | 119 | 147 | 234 | 335 | 386 | 438 | 380 | 346 | 273 | 185 | |
| Unknown | 11 | 15 | 23 | 32 | 33 | 55 | 43 | 40 | 32 | 18 | |
| T stage | <0.01 | ||||||||||
| T1 | 587 | 1,112 | 2,312 | 3,641 | 5,187 | 6,620 | 6,270 | 5,117 | 3,122 | 1,258 | |
| T2 | 862 | 1,663 | 3,421 | 5,308 | 7,216 | 9,032 | 8,370 | 7,564 | 5,007 | 2,316 | |
| T3 | 201 | 368 | 766 | 1,197 | 1,454 | 1,769 | 1,606 | 1,338 | 872 | 375 | |
| T4 | 1,484 | 2,410 | 4,419 | 6,384 | 8,149 | 8,889 | 8,515 | 7,432 | 5,353 | 2,953 | |
| M stage | <0.01 | ||||||||||
| M0 | 1,426 | 2,733 | 5,626 | 9,021 | 12,812 | 16,131 | 15,447 | 13,589 | 8,914 | 4,336 | |
| M1 | 1,684 | 2,764 | 5,200 | 7,350 | 9,003 | 9,923 | 9,050 | 7,625 | 5,235 | 2,437 | |
| Unknown | 24 | 56 | 92 | 159 | 191 | 256 | 264 | 237 | 205 | 129 | |
| Year of diagnosis | <0.01 | ||||||||||
| 2004 | 337 | 512 | 877 | 1,344 | 1,777 | 2,069 | 2,025 | 1,818 | 1,063 | 426 | |
| 2005 | 318 | 524 | 873 | 1,355 | 1,767 | 2,011 | 1,982 | 1,768 | 1,142 | 437 | |
| 2006 | 332 | 582 | 1,010 | 1,460 | 1,877 | 2,199 | 2,168 | 1,855 | 1,205 | 542 | |
| 2007 | 305 | 587 | 966 | 1,491 | 2,058 | 2,430 | 2,277 | 1,979 | 1,233 | 565 | |
| 2008 | 298 | 583 | 1,096 | 1,566 | 2,124 | 2,602 | 2,310 | 2,056 | 1,365 | 653 | |
| 2009 | 309 | 609 | 1,142 | 1,673 | 2,319 | 2,622 | 2,537 | 2,205 | 1,501 | 728 | |
| 2010 | 302 | 573 | 1,272 | 1,842 | 2,357 | 2,932 | 2,661 | 2,374 | 1,661 | 822 | |
| 2011 | 339 | 569 | 1,298 | 1,852 | 2,569 | 3,046 | 2,784 | 2,383 | 1,725 | 821 | |
| 2012 | 303 | 537 | 1,226 | 2,007 | 2,589 | 3,237 | 2,961 | 2,557 | 1,794 | 932 | |
| 2013 | 291 | 477 | 1,158 | 1,940 | 2,569 | 3,162 | 3,056 | 2,456 | 1,665 | 976 | |