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. 2019 Jul 2;10:1451. doi: 10.3389/fimmu.2019.01451

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Copyright © 2019 Watson, Dai, Zheng, Nakano, Giannou, Menk, Stolz, Delgoffe and Thomson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TORC2^−/− DC exhibit a distinct gene expression profile from wild-type (WT) control (Ctrl) DC. (A) Expression of 378 genes comprised in the NanoString Mouse Immunology Panel, shown as a heat map. Red indicates increased gene expression and green indicates decreased gene expression compared to Ctrl DC; n = 2 mice in each group. (B) Selection highlighting 5 genes of interest,- upstream mediators of augmented Akt/TORC1 activity from the panel in (A), that were upregulated in TORC2^−/− compared with Ctrl DC. (C) Expression of Srebf1, Pparγ, and Yy1 mRNA determined by RT-PCR in WT Ctrl DC and TORC2^−/− DC and normalized to the housekeeping gene GAPDH, with Ctrl DC as the referent control; n = 5 mice per group, Student's “t”-test, *p < 0.05; NS, not significant.