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. 2019 Jul 5;10:1472. doi: 10.3389/fimmu.2019.01472

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Copyright © 2019 Hook, Cao, Potera, Alsmadi, Schmidtke and Moreland.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nox2 represses NET formation in the lung following systemic inflammation. (A) Enhanced NET formation is evident as measured by the number of H3CIT positive neutrophils in the lungs of the gp91^phox(−/y) mice 24 h after SIRS induction by intraperitoneal injection of zymosan as compared with WT mice or saline injection, N = 2 saline injected, and 5–7 zymosan injected, ^****p < 0.0001. (B–E) Representative lung sections demonstrating dual staining for myeloperoxidase (green) and H3CIT (red) in WT (B–C) and gp91^phox(−/y) (D–E) mice 24 h after SIRS induction. DAPI was used to identify the nucleus.