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. 2019 Jul 5;10:1472. doi: 10.3389/fimmu.2019.01472

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Copyright © 2019 Hook, Cao, Potera, Alsmadi, Schmidtke and Moreland.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nox2 represses PAD4 activity in the lung following systemic inflammation. (A,B) Lung sections from a gp91^phox−/y mouse 24 h following injection of intraperitoneal zymosan demonstrate nuclear localization of PAD4 (green), co-localizing with DAPI (blue) and granular localization of myeloperoxidase (red) staining. (C) PAD4 activity in the supernatant recovered from whole lung digest of mice at baseline (n = 5) and 24 h (n = 11) following injection of zymosan, ^**p < 0.05.