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. 2018 Dec 27;10(4):909–914. doi: 10.1111/jdi.12978

Figure 2.

Figure 2

Oral glucose tolerance tests (OGTTs) and insulin tolerance tests (ITTs) in ovariectomized mice. OGTT and ITT in wild‐type (WT; white circles and bars), green fluorescent protein inserted into the glucose‐dependent insulinotropic polypeptide (GIP) locus, in which the GIP locus was reduced (GIPgfp/+; gray circles and bars) and absent (GIPgfp/gfp; black circles and bars) mice. OGTTs were carried out at (a–c) 17 weeks‐of‐age in cohort 1 (n = 6) and (e–g) 37 weeks‐of‐age in cohort 2 (n = 7). ITTs were carried out at (d) 24 weeks in cohort 1 (n = 4‐6) and (h) 40 weeks in cohort 2 (n = 7). (a,e) Blood glucose levels, (b,f) plasma insulin levels during OGTTs, (c,g) plasma total GIP levels during OGTTs and (d,h) blood glucose levels during ITTs as the percentage change from fasting glucose levels. The area under the curves (AUC) are shown in the upper right panel of each figure. *P < 0.05, **P < 0.01, ***P < 0.001 compared with WT. NS, not significantly different.