Table 3.
Genotypes frequencies of rs11085721 in DNMT1 according to the status of cardiovascular autonomic neuropathy in individuals with type 1 diabetes sorted by sex
| rs11085721 | Without CAN | With CAN | OR (95% CI) | P‐value |
|---|---|---|---|---|
| DNMT1 | ||||
| Female T1D | ||||
| n | 141 | 72 | 2.32 (1.26–4.33) | 0.006 |
| GG | 0.702 | 0.514 | ||
| GC | 0.277 | 0.458 | ||
| CC | 0.021 | 0.028 | ||
| MAF | 0.169 | 0.250 | ||
| Male T1D | ||||
| n | 97 | 49 | 0.89 (0.28–2.59) | 0.84 |
| GG | 0.773 | 0.794 | ||
| GC | 0.213 | 0.206 | ||
| CC | 0.014 | 0.000 | ||
| MAF | 0.120 | 0.103 | ||
Odds ratio (OR) for the minor allele determined in logistic regression in a co‐dominant model analyses adjusted for glycated hemoglobin, triglycerides, estimated glomerular filtration rate, the presence of hypertension and use of medicines (angiotensin‐converting enzyme inhibitors and statins). P ≤ 0.01 is considered significant. Power of analysis: 0.84. CAN, cardiovascular autonomic neuropathy; CI, confidence interval; MAF, minor allele frequency; T1D, type 1 diabetes.