Table 3.

Results of the multiple linear regression analysis of the fibrosis‐4index and 7S domain of type IV collagen (n = 176) and the insulin‐like growth factor‐1 and insulin‐like growth factor‐1 standard deviation score

	Age‐adjusted				Model 1				Model 2
	β	B	95% CI (Low, High)	P value	β	B	95% CI (Low, High)	P value	β	B	95% CI (Low, High)	P value
FIB‐4 index
n = 415
IGF‐1	NA	NA	NA	NA	−0.32	−0.007	−0.009, −0.005	<0.0001	−0.29	−0.006	−0.009, −0.004	<0.0001
IGF‐1 SDS	NA	NA	NA	NA	−0.22	−0.17	−0.24, −0.09	<0.0001	−0.22	−0.17	−0.25, −0.10	<0.0001
IV‐7S
n = 176
IGF‐1	−0.40	−0.009	−0.01, −0.006	<0.0001	−0.24	−0.006	−0.009, −0.002	0.004	−0.27	−0.007	−0.01, −0.003	0.0004
IGF‐1 SDS	−0.44	−0.34	−0.44, −0.24	<0.0001	−0.27	−0.20	−0.31, −0.09	0.0004	−0.30	−0.23	−0.34, −0.13	<0.0001

The 95% confidence intervals (CI) were expressed as (Low, High). Fibrosis‐4 (FIB‐4) index: model 1 was adjusted for the following factors: sex, body mass index (BMI), fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), visceral fat area (VFA), systolic blood pressure (SBP), triglyceride (TG), high‐density lipoprotein cholesterol (HDL‐C), gamma glutamyl transpeptidase (γ‐GTP) and growth hormone (GH). Model 2 was adjusted for factors that were found to be an independent variable in univariate analyses, such as BMI, FPG, HbA1c, VFA, TG, HDL‐C, γ‐GTP, glimepiride, glinides and statins. IV‐7S: Model 1 was adjusted for the following factors: age, sex, BMI, FPG, HbA1c, VFA, SBP, TG, HDL‐C, AST, ALT, γ‐GTP, platelets and GH. Model 2 was adjusted for factors that were found to be an independent variable in univariate analyses, such as age, VFA, AST, ALT, γ‐GTP and platelets. ALT, alanine aminotransferase; AST, aspartate aminotransferase; B, partial regression coefficient; IGF‐1, insulin‐like growth factor‐1; IV‐7S, 7S domain of type IV collagen.