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. 2019 Jun 20;13(1):61–75. doi: 10.1016/j.stemcr.2019.05.023

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

A Model for the Role of DPY30 in HSPC through Regulation of Energy Metabolism and Genome Integrity

(A) DPY30 normally ensures the functionality of HSPC through guarding genome integrity and regulating key maintenance genes. It also enables HSC activation by regulating genes in energy metabolism.

(B) DPY30 loss results in dysregulation of metabolism and key maintenance gene expression, as well as breach of genome integrity. These stresses induce P21 and other responses that lead to stem cell loss and activation defect.