Table 1.

Demographic and clinical data for each diagnostic group.

	A-EOAD (n = 38)	NA-EOAD (n = 20)	FTD (n = 20)	Young HC (n = 16)	LOAD (n = 30)	Older HC (n = 16)
Gender (% Female)	57.9	60	45	62.5	60	46.7
Age Mean	61.3 ± 5	59.7 ± 5.7	61.1 ± 4.4	57.5 ± 3.3	71.3 ± 5.2a	74.7 ± 3.9a
AAO Mean	58.3 ± 4.7	57.2 ± 5.5	58.1 ± 4.4	–	72.2 ± 4.9b	–
Time to diagnosis	3 ± 1.5	2.5 ± 1.3	3 ± 2.2	–	2.4 ± 2.2	–
MMSE score	24.3 ± 2.6	25.1 ± 3	25.8 ± 2.8	29 ± 1.2c	24.2 ± 3	28.4 ± 0.7c
APOE Ɛ4 (%)	65.8d	35	20	18.8	55.2f	6.7
CSF Aβ42 (pg/mL)	397.6±108e	366.28±124e	851.1 ± 305	893.2 ± 247	358.2±105e	733 ± 185
CSF p-tau (pg/mL)	108.6±36e	112.1±44e	48.6 ± 18	51.4 ± 9	95±47e	59.3 ± 17
CSF t-tau (pg/mL)	748.3±426e	701.9±382e	327.6 ± 158	224.3 ± 52	677±439e	299.1 ± 116

Data are presented as means ± standard deviation. A-EOAD, Amnesic Early Onset Alzheimer's disease; NA-AEOD, Non-Amnesic Early Onset Alzheimer's disease; FTD, Frontotemporal Dementia; HC, Healthy Controls; AAO, Age At Onset.

^aStatistically significant (p < .01) differences compared to A-EOAD, NA-EOAD, FTD, Young HC.

^bStatistically significant (p < .01) differences compared to A-EOAD, NA-EOAD, FTD.

^cStatistically significant (p < .01) differences compared to A-EOAD, NA-EOAD, FTD and LOAD.

^dStatistically significant (p < .05) differences compared to NA-EOAD, FTD, LOAD and young and older HC.

^eStatistically significant (p < .05) differences compared to FTD, young and older HC.

^fStatistically significant (p < .05) differences compared to older HC.