Table 2.
The frequencies and effect sizes of the three tested BARD1 variants.
| Study Population | Group | p.Q564X | p.R658C | p.R659R | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M + /N (%) | OR | 95%CI | p-Value | M+/N (%) | OR | 95%CI | p-Value | M+/N (%) | OR | 95%CI | p-Value | ||
| Controls | P | 7/4707 (0.15) | - | - | - | 26/4707 (0.55) | - | - | - | 14/4707 (0.30) | - | - | - |
| B | 0/1189 (0.00) | - | - | - | - | - | - | - | - | - | - | - | |
| P + B | 7/5896 (0.12) | - | - | - | - | - | - | - | - | - | - | - | |
| All BC patients | P | 34/12,476 (0.27) | 1.83 | 0.81–4.14 | 0.14 | 80/12,476 (0.64) | 1.16 | 0.75–1.81 | 0.51 | 49/12,476 (0.39) | 1.32 | 0.73–2.40 | 0.36 |
| B | 4/1459 (0.27) | n.a. | n.a. | n.a. | - | - | - | - | - | - | - | - | |
| P + B | 38/13,935 (0.27) | 2.30 | 1.03–5.15 | 0.04 | - | - | - | - | - | - | - | - | |
| 2.24 * | 0.99–5.03 * | 0.05 * | - | - | - | - | - | - | |||||
| 2.12 ** | 0.97–4.62 ** | 0.06 ** | - | - | - | - | - | - | |||||