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. 2019 Jun 17;11(6):834. doi: 10.3390/cancers11060834

Figure 1.

Figure 1

Angiogenesis enrichment score comparing relapsed vs. non-relapsed tumours. Scores were generated from expression data by gene set variation analysis (Gene Set Variation Analysis (GSVA) function). The gene set “Biocarta VEGF Pathway” from MSigDatabase (which includes genes related to hypoxia, blood vessels formation, and pro-angiogenic factors) was used (http://software.broadinstitute.org/gsea/msigdb/cards/BIOCARTA_VEGF_PATHWAY). Groups were compared by non-parametric Wilcoxon rank test. Data were extracted from The Cancer Genome Atlas (TCGA) database through cBioPortal (TCGA-UVM, 80 primary samples); expression data were downloaded as normalized Fragments Per Kilobase of exon per million fragments Mapped (FPKM) values and log2 transformed. VEGF: vascular endothelial growth factor.