Table 3.
Associations between EGFR/CCND1 copy number and clinicopathological parameters.
| EGFR | CCND1 | EGFR/CCND1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Di | Poly | Amp | P Value | N | Amp | P Value | Di/Neu | Others | Amp/CNA | P Value | |
| Age (years) | |||||||||||
| <50 | 90 (64) | 17 (12) | 34 (24) | 0.11 | 63 (45) | 78 (55) | 0.32 | 51 (36) | 51 (36) | 39 (28) | 0.04 |
| ≥50 | 88 (76) | 10 (9) | 18 (16) | 0.04a | 59 (51) | 57 (49) | 48 (41) | 51 (44) | 17 (15) | 0.06 a | |
| Subsites | |||||||||||
| Tongue | 63 (70) | 9 (10) | 18 (20) | 0.97 | 41 (46) | 49 (54) | 0.90 | 38 (42) | 28 (31) | 24 (27) | 0.24 |
| Bucca | 63 (67) | 10 (11) | 21 (22) | 0.82 a | 46 (49) | 48 (51) | 35 (37) | 39 (41) | 20 (21) | 0.77 a | |
| Others | 52 (71) | 8 (11) | 13 (18) | 35 (48) | 38 (52) | 26 (36) | 35 (48) | 12 (16) | |||
| Clinical stage | |||||||||||
| I/II | 52 (80) | 8 (12) | 5 (8) | 0.01 | 38 (58) | 27 (44) | 0.04 | 33 (51) | 24 (37) | 8 (12) | 0.03 |
| III/IV | 126 (66) | 19 (10) | 47 (24) | <0.01 a | 84 (44) | 108 (56) | 66 (34) | 78 (41) | 48 (25) | <0.01a | |
| Primary tumor status | |||||||||||
| T1/T2 | 90 (74) | 12 (10) | 19 (16) | 0.20 | 60 (50) | 61 (50) | 0.52 | 51 (42) | 48 (40) | 22 (18) | 0.34 |
| T3/T4 | 88 (65) | 15 (11) | 33 (24) | 0.07 a | 62 (46) | 74 (54) | 48 (35) | 54 (40) | 34 (25) | 0.15 a | |
| LNM c | |||||||||||
| No | 103 (78) | 14 (11) | 15 (11) | <0.01 | 80 (61) | 52 (39) | <0.01 | 67 (51) | 49 (37) | 16 (12) | <0.01 |
| Yes | 75 (60) | 13 (10) | 37 (30) | <0.01 a | 42 (34) | 83 (66) | 32 (26) | 53 (42) | 40 (32) | <0.01a | |
| ECSd | |||||||||||
| Yes | 45 (59) | 9 (12) | 22 (29) | 0.82 | 32 (42) | 44 (58) | 0.02 | 23 (30) | 31 (41) | 22 (29) | 0.33 |
| No | 29 (60) | 4 (8) | 15 (31) | 0.95 a | 10 (21) | 38 (79) | 9 (19) | 21 (44) | 18 (38) | 0.15 a | |
| Tumor differentiation | |||||||||||
| Well | 77 (79) | 9 (9) | 12 (12) | 0.03 | 63 (64) | 36 (36) | <0.01 | 57 (58) | 27 (27) | 15 (15) | <0.01 |
| Mod/Poor | 101 (64) | 18 (11) | 40 (25) | <0.01 a | 59 (38) | 98 (62) | 42 (27) | 74 (47) | 41 (26) | <0.01 a | |
| AQ e chewing | |||||||||||
| Yes | 156 (70) | 21 (9) | 46 (21) | 0.34 | 110 (49) | 113 (51) | 0.13 | 89 (40) | 88 (39) | 46 (21) | 0.39 |
| No | 22 (65) | 6 (18) | 6 (18) | 0.88 a | 12 (35) | 22 (65) | 10 (29) | 14 (41) | 10 (29) | 0.17 a | |
| Cigarette smoking | |||||||||||
| Yes | 153 (70) | 23 (10) | 44 (20) | 0.97 | 107 (49) | 113 (51) | 0.36 | 86 (39) | 88 (40) | 46 (21) | 0.70 |
| No | 25 (68) | 4 (11) | 8 (22) | 0.80 a | 15 (41) | 22 (59) | 13 (35) | 14 (38) | 10 (27) | 0.46 a | |
| Alcohol drinking | |||||||||||
| Yes | 96 (70) | 14 (10) | 28 (20) | 0.98 | 57 (41) | 81 (59) | 0.03 | 46 (33) | 61 (44) | 31 (22) | 0.16 |
| No | 82 (69) | 13 (11) | 24 (20) | 0.96a | 65 (55) | 54 (45) | 53 (45) | 41 (34) | 25 (21) | 0.18a | |
a By chi-square trend test; b EGFR CNA’s contain EGFR polysomy or EGFR amplification cases; c LNM: lymph node metastasis; d ECS: extra-capsular spread; e AQ: areca quid; Di: disomy; Poly: polysomy; Amp: amplification; Neu: copy number neutral.