Table 1.
Novel mycobacterial target examples and their relevant compounds or compound classes.
| Targeted Pathway | Target | Relevant Compound (Class) |
|---|---|---|
| Cell wall biosynthesis | DprE1 | BTZ043 (BTZ) |
| DprE1 | PBTZ169 (PBTZ) | |
| DprE1 | TBA7371 (1,4-azaindole) | |
| DprE1 | OPC167832 (1,3-dihydrocarbostyril) | |
| MmpL3 | SQ109 (1,2-ethylenediamine) | |
| Cell wall biosynthesis and Protein synthesis | - | Pretomanid/PA-824 (nitroimidazole) |
| - | Delamanid (nitroimidazole) | |
| Oxidative phosphorylation | AtpE | BDQ (DARQ) |
| ATP synthase | Squaramides | |
| QcrB | Q203 (imidazopyridine) | |
| QcrB | Pyrrolo[3,4-c]pyridine-1,3(2H)-diones | |
| QcrB | 2-(Quinolin-4-yloxy)acetamides | |
| QcrB | AX-35 (arylvinylpiperazine amide) | |
| Protein synthesis | GyrA | Thiophenes |
| GyrB | SPR720 (aminobenzimidazole) | |
| DNA-dependent RNA polymerase | AAPs | |
| LeuRS | GSK656 (oxaborole) | |
| Bacillary redox homeostasis | MshC | Dequalinum |
| Mtr | Benzo[g]isoquinoline-5,10-diones | |
| Mtr | Benzo[j]phenanthridine-7,12-diones |