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Representation of the mechanisms of action of microglial actin-interacting proteins. (A) The process of branching is regulated by the Arp2/3 complex, (B) which is recruited by CORO1A to an existing actin filament. Arp2/3 engages with G-actin to form a filament branch. (C) Iba1 promotes the formation of parallel actin bundles, scaffold-like structures that give shape to lamellipodia and filopodia. (D) CFL1 depolymerizes filaments to make G-actin available to form new actin structures.
