Table 1.
Significant PCOS–disease subnetworks. Significant subnetworks with shared PCOSrps, suggesting diseases association with PCOS.
| PCOS–Disease Subnetwork | Density Score | Number of Nodes | Number of Interactions | PCOS-Associated Disease | Shared PCOSrps |
|---|---|---|---|---|---|
| 1 | 17.882 | 18 | 152 | Migraine | RPS7, RPS10, RPS26 |
| 8 | 5.5 | 25 | 66 | Ovarian cancer | BRCA1, CDKN1B, PPP1CC, SKP2, URI1 |
| 26 | 3.5 | 5 | 7 | Schizophrenia | HLA-A, HLA-C, HLA-E, LILRB1 |
| 28 | 3.357 | 29 | 47 | Hypertension | BBS1, BBS2, JUN, MYH9, SMAD4 |
| 31 | 3.333 | 4 | 5 | Anemia | HBA1, HBBHBA1, HBB |
| Polycythemia vera | |||||
| 34 | 3.067 | 91 | 138 | Schizophrenia | ACTB, AKT1, AR, BID, BLOC1S3, CSNK1D, DBN1, ENO2, FGFR1, FN1, GABARAP, GRB10, HDAC3, HMGA1, PAK2, PPARG, RB1CC1, S100B, SNAP29, TGFB1, TPI1, VAMP7, YWHAE |
| Depressive disorder | AKT1, APP, AR, ATF3, CSNK1D, FGFR1, HIF1A, MAPT, OPTN, PRKACA, S100B, TGFB1, VCP | ||||
| Obesity | AKAP1, AKT1, DDIT3, NR0B2, PARP1, PPARG, PRKAR2B, PRPF31 | ||||
| 35 | 3.043 | 24 | 35 | Acute kidney injury | EGFR, GSTM2, TP53 |
| 39 | 3 | 9 | 12 | Gastrointestinal hemorrhage | FGA, FGB, FGG |
| Pulmonary embolism | FGA, PLAT | ||||
| 51 | 3 | 3 | 3 | Syncope | CACNA1C, RYR2 |
| 55 | 3 | 3 | 3 | Endometriosis | AKR1C1, AKR1C2, AKR1C3 |
| Osteoarthritis | AKR1C1, AKR1C2 | ||||
| 56 | 3 | 3 | 3 | Hallucinations | BCKDHA, BCKDHB |
| 68 | 3 | 3 | 3 | Hyperkalemia | SCNN1A, SCNN1G |
| Hypotension | SCNN1A, SCNN1G |