Table 2.
Shared PCOS–disease pathways. These pathways were shared between PCOS and respective diseases identified from pathway enrichment analysis.
| PCOS–Disease Subnetwork | PCOS-Associated Disease | Shared Pathway |
|---|---|---|
| 1 | Migraine | Ribosome |
| 8 | Ovarian cancer | Long-term potentiation |
| 26 | Schizophrenia | Antigen processing and presentation |
| 28 | Hypertension | Mitophagy |
| 31 | Anemia and polycythemia vera | No enriched pathway |
| 34 | Schizophrenia, depressive disorder, and obesity | Longevity regulation pathway, necroptosis, apoptosis, regulation of actin cytoskeleton, autophagy, p53 signaling pathway, and SNARE interactions in vesicular transport |
| 35 | Acute kidney injury | Adherens junction, glutathione metabolism |
| 39 | Pulmonary embolism and gastrointestinal hemorrhage | Compliment and coagulation cascades |
| 51 | Syncope | No enriched pathway |
| 55 | Endometriosis and osteoarthritis | Steroid hormone biosynthesis |
| 56 | Hallucinations | No enriched pathway |
| 68 | Hyperkalemia and hypotension | No enriched pathway |