Table A1.
Subnetworks generated from MCODE.
| Cluster | Score (Density × #Nodes) | #Nodes | Edges | PCOSrps |
|---|---|---|---|---|
| 1 | 17.882 | 18 | 152 | RPL10, RPS10, RPS13, RPS14, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS25, RPS26, RPS3A, RPS5, RPS6, RPS7, RPS8, RPS9, VCAM1 |
| 2 | 15.4 | 41 | 308 | ADRM1, CCDC74B, CDK19, CDK8, ESR1, MED12, MED14, MED15, MED17, MED19, MED20, MED21, MED30, MED4, MED6, MED7, MED9, PAAF1, POMP, PSMA1, PSMA2, PSMA3, PSMA4, PSMB1, PSMB3, PSMB4, PSMB5, PSMB8, PSMB9, PSMC1, PSMC2, PSMC3, PSMC4, PSMC6, PSMD10, PSMD11, PSMD12, PSMD2, PSMD3, PSMD7, UCHL5 |
| 3 | 8 | 9 | 32 | C1D, DIS3, EXOSC2, EXOSC3, EXOSC4, EXOSC6, EXOSC7, EXOSC8, EXOSC9 |
| 4 | 7.607 | 57 | 213 | ACTL6A, ARID1A, ARID1B, CCNA1, CCT2, CCT3, CCT6A, CCT7, CCT8, CDK2AP1, CDT1, CHD4, DPF3, EPC1, FZR1, GATAD2A, IGBP1, ING3, INO80B, INO80C, INO80D, INO80E, MBD3, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MORF4L1, MORF4L2, MTA1, NFRKB, PLK1, POLR2A, POLR2B, POLR2D, POLR2E, POLR2G, POLR2J, PPP2CB, PPP4C, RBBP4, RUVBL1, RUVBL2, SLMAP, SMARCA2, SMARCC1, SMARCC2, SMARCD1, SSRP1, STK24, STRN3, STRN4, TCP1, YEATS4, YY1 |
| 5 | 6.333 | 7 | 19 | BRD4, CHTF18, DSCC1, RFC2, RFC3, RFC4, RFC5 |
| 6 | 6 | 7 | 18 | SUPT3H, SUPT7L, TADA1, TADA2B, TADA3, TAF12, USP22 |
| 7 | 6 | 7 | 18 | LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, USP15 |
| 8 | 5.5 | 25 | 66 | BRCA1, CDK1, CDK5, CDKN1B, CKS1B, CREBBP, DDX17, DSN1, KNL1, NCOA1, NCOA2, NDC80, NSL1, NUF2, PPP1CA, PPP1CC, RPAP3, RUNX1, SKP2, SPC24, SPC25, URI1, UXT, VDR, ZWINT |
| 9 | 5 | 5 | 10 | RPL13, RPL21, RPL36, RPL7A, RPLP0 |
| 10 | 5 | 5 | 10 | NUP37, NUP43, NUP85, SEC13, SEH1L |
| 11 | 4.857 | 8 | 17 | CCDC93, COMMD1, COMMD10, COMMD2, COMMD4, COMMD6, ELOC, SOCS1 |
| 12 | 4.8 | 6 | 12 | ABI1, ABI2, CYFIP1, CYFIP2, WASF2, ZNF511 |
| 13 | 4.571 | 8 | 16 | MRPL1, MRPL12, MRPL42, MRPL44, MRPL50, MRPL51, MRPL55, MRPL58 |
| 14 | 4.5 | 5 | 9 | CTTNBP2NL, FGFR1OP2, PDCD10, PPP2R1A, STRIP1 |
| 15 | 4.259 | 55 | 115 | ARMC8, BARD1, BCL3, BCLAF1, BRCA2, BRCC3, CARM1, CDCA5, CLK2, CTNNB1, DDX5, FOS, GPS2, ILF2, LUC7L2, MAEA, MET, MRE11, NBN, NCOA3, NDRG1, NOP2, NOP56, NR3C1, NXF1, PDS5A, PDS5B, PGR, PPARGC1A, PRG2, RAD21, RAD50, RANBP2, RANBP9, RELA, RNPS1, RPL14, RPL15, RPL18, RPL18A, RPL23A, RPL24, RPL26, RPL37A, SMC1A, SMC3, SRPK2, SRRM1, SRRM2, SUMO3, TBL1X, TBL1XR1, TRA2A, TRIM28, WAPL |
| 16 | 4.027 | 76 | 151 | ACTR1B, ACTR3, ARPC2, ARPC3, ARPC4, ATF4, BHLHE40, BORCS6, CBLB, CEBPG, CFLAR, CSPP1, DCTN1, DCTN2, DCTN5, DCTN6, DNMT1, DNMT3B, EAF1, ERBB3, ETS1, EWSR1, EZR, FADD, FAS, FOSL1, GADD45A, GADD45G, GPR137B, HAUS1, HAUS2, HAUS4, HAUS5, HAUS6, HAUS7, HDAC1, HDAC2, IDI2, INSR, KDM1A, LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4, LMO4, LUC7L, MAF, MAP2K1, MAP2K2, MAPK3, NCAPD2, NCAPG, NCAPH, NCOR2, NPM1, PIK3R1, PRMT1, PTMA, PTPN11, RAF1, RRAGC, SMC2, SMC4, SOCS3, SSBP2, SSBP3, SSBP4, SUZ12, SYK, TAF1D, TDG, TOP2A, TRADD, UBE2I, ZEB2, ZHX1 |
| 17 | 4 | 4 | 6 | GSE1, HMG20A, HMG20B, RCOR3 |
| 18 | 4 | 4 | 6 | APBA1, CASK, KCNJ12, LIN7B |
| 19 | 4 | 4 | 6 | MRPS2, MRPS31, MRPS5, PTCD3 |
| 20 | 4 | 4 | 6 | IFT122, IFT43, TULP3, WDR35 |
| 21 | 4 | 4 | 6 | ARCN1, COPA, COPG1, COPZ1 |
| 22 | 4 | 4 | 6 | POLE, POLE2, POLE3, POLE4 |
| 23 | 3.882 | 35 | 66 | ANAPC1, ANAPC10, ANAPC16, ANAPC5, BUB1B, CBX1, CBX3, CDC23, CDC7, CHAF1A, CHAF1B, DBF4, EMSY, EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC7, GATAD1, KDM5A, KPNA2, KPNB1, MDC1, MYC, NUP153, NUP62, PENK, PHF12, PPP2R5A, PPP2R5D, RBL1, SGO1, SIN3B, SMAD3 |
| 24 | 3.689 | 46 | 83 | ANAPC4, BUB3, CCDC8, CDC25A, CDC25B, CDC25C, CDC27, CDC37, CUL4A, CUL7, DCAF5, DDA1, FAAP100, FAAP20, FANCB, FANCG, FANCM, IRS1, IRS2, LATS1, LATS2, MAD2L1, MAP3K5, MAPK14, NEK2, NF2, NTRK1, OBSL1, PHLPP2, POLA1, POLA2, PRIM1, PRIM2, RAE1, RASSF8, RB1, SET, STK11, STK4, TTLL1, UBTF, USP12, USP46, WDR20, WDR48, YWHAH |
| 25 | 3.5 | 5 | 7 | SNAP23, STX6, STXBP5, VAMP2, VAMP3 |
| 26 | 3.5 | 5 | 7 | HLA-A, HLA-C, HLA-E, HLA-F, LILRB1 |
| 27 | 3.5 | 5 | 7 | CCND2, CCND3, CDK4, CDK6, CDKN2C |
| 28 | 3.357 | 29 | 47 | ATF7, BBIP1, BBS1, BBS2, BBS7, CDK2, CREB5, DNAJB1, E2F1, FOXO3, HNRNPD, HSPA1A, HSPA4, HUWE1, JUN, JUNB, MAPK9, MCL1, MDM2, MYH9, NFATC2, PPP1CB, PPP1R10, PTBP1, SMAD4, STUB1, TOX4, TRIM33, TTC8 |
| 29 | 3.333 | 4 | 5 | ASF1A, ASF1B, NASP, TONSL |
| 30 | 3.333 | 4 | 5 | DMD, DTNA, SNTA1, SNTB1 |
| 31 | 3.333 | 4 | 5 | HBA1, HBB, NDUFAF5, PGPEP1 |
| 32 | 3.333 | 4 | 5 | CDC42EP3, SEPT2, SEPT6, SEPT7 |
| 33 | 3.25 | 9 | 13 | AMFR, AP2A2, AP2M1, AP2S1, CFTR, DAB2, DERL2, SELENOS, SYVN1 |
| 34 | 3.067 | 91 | 138 | ACTB, ACTN1, AES, AKAP1, AKAP11, AKT1, APP, AR, ARHGEF7, ATF3, BAX, BCL2L2, BID, BLOC1S1, BLOC1S3, BLOC1S6, CASP8, CDKN1A, CEBPB, CSNK1D, DAG1, DBN1, DBNL, DDIT3, EEA1, ENO2, FGFR1, FN1, GABARAP, GIT1, GIT2, GRB10, HDAC3, HIF1A, HMGA1, HNRNPH1, ITGA5, JAK2, JUP, LGALS8, MAP1LC3A, MAPK8IP1, MAPRE1, MAPT, NCBP1, NR0B2, OPTN, PA2G4, PAK2, PARP1, PARP2, PKM, PMAIP1, PPARG, PRKACA, PRKAR2A, PRKAR2B, PRKDC, PRLR, PRPF31, PTPRK, RAB5A, RABEP1, RABGEF1, RB1CC1, RIPK1, RNF146, S100B, SHB, SIAH2, SIRT2, SNAP29, SNAPIN, SSX2IP, STX3, STX4, STX7, STXBP1, TERF1, TGFB1, TGFB1I1, TGFB2, TGFBR3, TPI1, TUBB3, UBD, VAMP7, VAV1, VCP, XPO1, YWHAE |
| 35 | 3.043 | 24 | 35 | ASH2L, CTNND1, CTTN, EGFR, GNAI1, GSTM2, GSTM3, GSTM4, HCFC2, HSP90AB1, IGF1R, KMT2B, KMT2C, MAPK8IP2, MTNR1B, NME1, PHB, RBBP5, RGS4, RRAD, TIAM1, TP53, TUBB, ZBTB33 |
| 36 | 3 | 3 | 3 | POP4, RBM4B, RPP25 |
| 37 | 3 | 3 | 3 | CCDC94, PLRG1, PRPF19 |
| 38 | 3 | 3 | 3 | CNOT3, CNOT7, TNRC6A |
| 39 | 3 | 9 | 12 | ACD, ALDH2, ANXA2, FGA, FGB, FGG, LDHA, PLAT, POT1 |
| 40 | 3 | 3 | 3 | FOXP1, FOXP2, FOXP4 |
| 41 | 3 | 3 | 3 | VPS26A, VPS29, VPS35 |
| 42 | 3 | 3 | 3 | CD81, CD9, TSPAN4 |
| 43 | 3 | 3 | 3 | TMED2, TMED3, TMED4 |
| 44 | 3 | 3 | 3 | CENPM, CENPO, CENPQ |
| 45 | 3 | 3 | 3 | THOC2, THOC3, THOC7 |
| 46 | 3 | 3 | 3 | EHMT2, H3F3A, KAT2B |
| 47 | 3 | 3 | 3 | DDX23, SNRNP40, SNRPD2 |
| 48 | 3 | 3 | 3 | FAF2, UFD1, VCPIP1 |
| 49 | 3 | 3 | 3 | CEP135, OFD1, PCM1 |
| 50 | 3 | 3 | 3 | GOLGA4, NOL11, UTP4 |
| 51 | 3 | 3 | 3 | CACNA1C, RYR2, SRI |
| 52 | 3 | 3 | 3 | EMC1, EMC2, EMC3 |
| 53 | 3 | 3 | 3 | FHIT, HSPD1, HSPE1 |
| 54 | 3 | 3 | 3 | SKA1, SKA2, SKA3 |
| 55 | 3 | 3 | 3 | AKR1C1, AKR1C2, AKR1C3 |
| 56 | 3 | 3 | 3 | BCKDHA, BCKDHB, PPM1K |
| 57 | 3 | 3 | 3 | MAB21L1, MEIS1, PBX1 |
| 58 | 3 | 3 | 3 | AP3D1, AP3M1, AP3S2 |
| 59 | 3 | 3 | 3 | MIS18A, MIS18BP1, OIP5 |
| 60 | 3 | 3 | 3 | C3, CFB, CFP |
| 61 | 3 | 3 | 3 | ANKRD55, IFT46, IFT74 |
| 62 | 3 | 3 | 3 | MTMR1, MTMR2, SBF1 |
| 63 | 3 | 3 | 3 | LMNA, PCBP1, YWHAZ |
| 64 | 3 | 3 | 3 | CUL3, KCTD10, KCTD13 |
| 65 | 3 | 3 | 3 | MAP3K7, STRADB, XIAP |
| 66 | 3 | 3 | 3 | SMC5, SMC6, STN1 |
| 67 | 3 | 3 | 3 | RAB3IP, TRAPPC10, TRAPPC2 |
| 68 | 3 | 3 | 3 | SCNN1A, SCNN1G, USP2 |
| 69 | 3 | 3 | 3 | FLNB, FLNC, OTUD1 |
| 70 | 3 | 3 | 3 | IFNAR2, IRF9, STAT2 |
| 71 | 3 | 3 | 3 | CALR, PDIA3, SLC2A1 |
| 72 | 2.868 | 77 | 109 | ACVR2A, AHCTF1, AP2B1, ATRX, BLNK, BMPR1A, BMPR2, CBX5, CRKL, DDX20, DDX3X, DOK1, EEF1E1, EIF2B1, EIF2B5, EIF4A2, EIF4G3, FKBP4, GDF5, GEMIN6, GPR183, HDAC5, HSP90AA1, IL1R1, IL1RAP, INPP5D, IRAK2, KARS, MRPL16, MRPL37, MRPL38, MRPL47, MRPL48, NEDD8, NIFK, NUP107, NUP205, NUP93, OSBPL10, OSBPL11, OSBPL9, OTUB1, P2RX4, PHB2, PLCG2, PRKD1, PTGER3, PTGES3, QKI, RARS, RBFOX1, RBFOX2, RBMX, RBPMS, RUNX3, SMAD1, SMAD5, SMURF2, SNRPB, SNRPF, SREK1, SRPK1, STAMBP, TAF1A, TAF1B, TAF1C, TBK1, TGFBR1, TOLLIP, UQCRB, UQCRC1, UQCRC2, UQCRQ, VAPA, VAPB, YTHDC1, ZBTB16 |
| 73 | 2.857 | 8 | 10 | ACTG1, GEMIN5, MLH1, MSH6, SNRPA1, SNRPD1, SNRPD3, SUMO2 |
| 74 | 2.8 | 6 | 7 | MYO5B, RAB11A, RAB11FIP2, RALBP1, REPS1, REPS2 |
| 75 | 2.667 | 4 | 4 | DNAAF2, H2AFY2, NUFIP1, SYN1 |
| 76 | 2.56 | 26 | 32 | ADRB2, ARRDC1, ATP6AP2, ATP6V0D1, ATP6V1D, BCL2, BNIP3, BNIP3L, CA8, CBX7, FAM175B, IGHG1, IGKC, ITPR1, L3MBTL2, MYO1C, NEK6, NEK7, NEK9, PHC3, PSME3, RING1, SNAPC1, SNAPC3, TMEM11, USP20 |
| 77 | 2.491 | 58 | 71 | ASAP1, ATXN3, CCNL2, CDK13, COG2, COG6, COL6A1, COL9A1, ERCC1, ERCC4, FAM122A, FRS2, FYN, GRB2, IQGAP1, KIT, LMNB1, LYN, MAG, MSH2, MSH3, MYL6, MYL6B, NRBF2, NTRK2, PCNA, PIK3C3, PIK3R4, PINK1, POU2F1, PPP3CA, PRKCB, PRKN, RCAN1, RP2, RRAS, SNX9, SPRY1, SPRY2, SQSTM1, SYNJ1, TMEM185A, TNK2, TNPO2, TOMM20, TOMM22, TOMM40, TUBA1A, TUBB4B, TXNRD1, UBA52, UBE4B, UBL7, USP32, VSIG2, XPA, XRCC5, YWHAB |