Table 2.
Bruton’s tyrosine kinase (BTK) expression and clinico-pathological parameters.
| Variables | BTK Intensity 1 | BTK Intensity 2 | BTK Intensity 3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| IHC < 1% | IHC ≥ 1% | p | IHC < 50% | IHC ≥ 50% | p | IHC < 80% | IHC ≥ 80% | p | |
| N = 38 | N = 47 | N = 75 | N = 11 | N = 70 | N = 15 | ||||
| Sidedness | |||||||||
| Right | 23 | 26 | 0.629 | 42 | 7 | 0.400 | 42 | 7 | 0.343 |
| Left | 15 | 21 | 33 | 3 | 28 | 8 | |||
| Grading | |||||||||
| G2 | 20 | 26 | 0.813 | 38 | 8 | 0.083 | 40 | 6 | 0.977 |
| G3 | 6 | 9 | 15 | 0 | 13 | 2 | |||
| Histotype | |||||||||
| Adenocarcinoma | 21 | 27 | 0.732 | 44 | 4 | 0.034 | 40 | 8 | 0.114 |
| Mucinous adenocarcinoma | 5 | 8 | 9 | 4 | 13 | 0 | |||
| KRAS | |||||||||
| Wild type | 5 | 4 | 0.498 | 37 | 6 | 0.533 | 39 | 4 | 0.161 |
| Mutated | 4 | 6 | 21 | 2 | 18 | 5 | |||
| Metastatic disease | |||||||||
| No | 16 | 27 | 0.241 | 8 | 1 | 0.596 | 8 | 1 | 0.937 |
| Yes | 12 | 11 | 8 | 2 | 9 | 1 | |||
| Age | |||||||||
| <70 | 28 | 30 | 0.403 | 49 | 9 | 0.127 | 48 | 10 | 0.826 |
| ≥70 | 10 | 16 | 25 | 1 | 21 | 5 | |||
| Sex | |||||||||
| M | 21 | 30 | 0.423 | 47 | 4 | 0.169 | 42 | 9 | 1.000 |
| F | 17 | 17 | 28 | 6 | 28 | 6 | |||
Values in bold are statistically significant.