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. 2019 Jul 8;13:2235–2247. doi: 10.2147/DDDT.S207315

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© 2019 Wang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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JAT induced apoptosis of colon cancer cells.

Notes: (A) The morphological features of HCT-116 and HT-29 cells stained by Hoechst 33342 under fluorescence microscope, the red arrow indicated obvious apoptosis (×400). (B) Flow cytometry measured mitochondrial transmembrane potential (△Ψm) by JC-1 cationic dye of HCT-116 and HT-29 cells. Data are expressed as mean of 590 nm emission spectrum of triplicate samples for JC-1 monomer/dimer ratio. (C) The apoptosis of HCT-116 and HT-29 cells was measured by flow cytometry after treated with JAT. (D) Western blotting was used to detect the expression of apoptosis-related proteins after treatment with JAT. Density of bands was quantified with Quantity One software. All values were presented as the mean±standard deviation (SD). *P<0.05, **P<0.01, and ***P<0.001 compared with control.

Abbreviation: JAT, jatrorrhizine.