Figure 1.

MicroRNA expression distinguishes imatinib-naïve (IM-n) from imatinib-resistant (IM-r) gastrointestinal stromal tumors (GIST). Fresh frozen tumor samples of IM-n and IM-r GIST patients were subjected to miRNA expression profiling. Depicted is the heat map of a supervised hierarchical clustering based on the 35 most significant (p < 0.01 and False Discovery Rate (FDR) < 20%) differentially expressed miRNAs. In the heat map red indicates relative high expression and green indicates relative low expression. The colored squares beneath the graph designate IM-n and IM-r samples, the malignancy risk and location of the tumors. Note that the sample codes below also indicate which KIT exon is mutated.