Table 1.
List of the main genetic alterations in AML that are associated with HOXA9 over-expression.
| Type of Alteration | Fusion/Mutation/Additional Chromosome | Translocation/Inversion/Deletion | References |
|---|---|---|---|
| Chromosomal alterations | MLL fusions | 11q23 translocations | [43,45,47] |
| NUP98-NSD1 | t(5;11)(q35;p15) | [80,82] | |
| NUP98-HOXA9 | t(7;11)(p15;p15) | [83] | |
| NUP98-HOXA10 | t(7;11)(p15;p15) | [84] | |
| NUP98-HOXC11 | t(11;12)(p15;q13) | [85] | |
| NUP98-HOXD11 | t(2;11)(q31;p15) | [86] | |
| NUP98-HOXD13 | t(2;11)(q31;p15) | [84] | |
| NUP98-HHEX | t(10;11)(q23;p15) | [87] | |
| NUP98-KDM5A | t(11;12)(p15;p13) | [33] | |
| NUP98-PHF23 | t(11;17)(p15;p13) | [33] | |
| NUP98-PRRX1 | t(1;11)(q24;p15) | [33] | |
| NUP98-DDX10 | inv(11)(p15q22) | [33] | |
| MYST3-CREBBP | t(8;16)(p11;p13) | [88] | |
| RUNX1-EVI1 | t(3;21)(q26;q22) | [89] | |
| CDX2-ETV6 | t(12;13)(p13;q12) | [90] | |
| CALM-AF10 | t(10;11)(p12-14;q14-21) | [91] | |
| SET-NUP214 | del(9)(q34.11;q34.13) | [92] | |
| NPM1-MLF1 | t(3;5)(q25;q34) | [93,94] | |
| +8 | / | [81] | |
| Mutations | NPM1 | [48,49,50,75] | |
| MLL-PTD | [42] | ||
| DNMT3A | [95] | ||
| EZH2 | [42] | ||
| IDH1/2 | [50,96] | ||
| Polymorphism | GFI1-S36N | [97] |