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. 2019 Jun 20;20(12):3007. doi: 10.3390/ijms20123007

Figure 4.

Figure 4

SERM2 promoted local gene expression of anti-inflammatory cytokines in distal colon, but not pro-inflammatory mediators or circulating modulators of inflammation. The relative fold change in gene expression in distal colon tissue, compared to DSS vehicle group of (A) Tnf, (B) Ccl2, (C) IL33, (D) Ifng, (E) Il10, (F) Il33, (G) Il4, (H) Adgre1, (I) Arg1. Bact was used as a house-keeping gene. The circulating concentration of (J) IL-5, (K) CCL-2, and (L) TNF in serum samples. The data are expressed as the mean with SD, one dot representing a tissue sample from single mouse (round dots in panels A–I indicate gene expression and square dots in panels J–L circulating proteins). p-values representing statistical significances for SERM-treatment were calculated using unparametric Mann–Whitney test vs. respective control.