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. 2019 Jun 12;11(6):1316. doi: 10.3390/nu11061316

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Aronia consumption maintains mRNA expression of endogenous antioxidant enzymes. Splenic CD4⁺CD62L⁺ cells from C57BL/6J mice were transferred to Rag1^-/- mice. Mice consumed the AIN-93M diet (colitic control) or aronia-supplemented diet for five weeks. A third group of Rag1^-/- mice received splenic CD4⁺ cells, consumed AIN-93M diet, and served as the non-colitic control. The mRNA expressions of transcription factor of Nfe2l2 (erythroid-derived 2-like 2) and the downstream antioxidant enzymes of Gclc (glutamate-cysteine ligase-catalytic subunit), Gsr (glutathione reductase), Sod2 (superoxide dismutase 2), Gpx1 (glutathione peroxidase 1), Gpx2 (glutathione peroxidase 2), and Prdx1 (peroxiredoxin 1) in the (A) colon (n = 4–5/group), (B) mesenteric lymph node (MLN) (n = 9–10/group), and (C) spleen (n = 3–5/group). Gene expression was normalized to Eef2 (eukaryotic translation elongation factor 2) and Rplp0 (ribosomal protein large P0) genes. Bars bearing different letters indicate significant differences between treatments (p < 0.05). Data are means ± SEMs.